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CAS NO.97-59-6
98%(500-1000)Kilogram98%(100-500)Metric Ton
| Molecular Formula | C4H6N4O3 |
| Molar Mass | 158.12 |
| Density | 1.6031 (rough estimate) |
| Melting Point | 230 °C (dec.) (lit.) |
| Boling Point | 283.17°C (rough estimate) |
| Flash Point | 230-234°C |
| Water Solubility | Slightly soluble in water. Freely soluble in alkalis |
| Solubility | Soluble in hot water, hot alcohol and dilute sodium hydroxide solution. Slightly soluble in water and alcohol at room temperature, hardly soluble in organic solvents such as ether and chloroform. |
| Appearance | White crystal |
| Color | White |
| Merck | 14,258 |
| BRN | 102364 |
| pKa | 8.96(at 25℃) |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.8500 (estimate) |
| MDL | MFCD00005260 |
| Physical and Chemical Properties | Appearance: white crystalline powder Melting Point: 226-240 ° C |
| Use | Widely used in various skin ulcers, wound treatment and nutritional cosmetics additives |
| What is allantoin | Allantoin belongs to an imidazole heterocyclic compound, is a derivative of uric acid, and belongs to a component of human skin. Uric acid acts as an antioxidant, and produces allantoin after free radical action. In 1912, Mocllster extracted allantoin from the underground stem of the plant. Allantoin can promote cell tissue growth, metabolism, softening stratum corneum protein. These properties are particularly pronounced when allantoin is applied to ulcerated and purulent skin, so it has the ability to accelerate wound healing and is a good active agent in the treatment of skin lesions. allantoin, once known as an anti-irritant, can effectively reduce the stimulation of irritants; At the same time, it is also an antioxidant, and like other water-soluble vitamins, its ability to aggregate free radicals is similar to that of vitamin C, so it can enhance the antioxidant capacity of cells. Therefore, the U. S. Food and Drug Administration FDA will be listed as the first class of efficient active component skin care agent, its non-toxic, non-irritating, no allergic reaction. |
| properties | pure product is a non-toxic, tasteless, non-irritating, non-allergic white crystals, crystallized in water as a single prism or colorless crystalline powder. Melting Point: 226-240 °c. Soluble in hot water, hot alcohol and dilute sodium hydroxide solution. Slightly soluble in water and alcohol at room temperature, difficult to dissolve in ether and chloroform and other organic solvents; Its saturated aqueous solution (concentration of 0.6%) is slightly acidic; PH 5.5. It is stable in an aqueous solution with a pH of 4 to 9. It is also stable in non-aqueous solvents and dry air; It can be decomposed by boiling in strong alkaline solution and sunlight exposure. |
| efficacy and function | 1. Emollient repair efficacy allantoin has good emollient effect, especially for the rough chapped skin, it can restore its smooth and moist, at the same time, it can enhance the water absorption capacity of the outermost layer of skin and hair, and improve the hydrophilicity of keratin molecules, the damaged stratum corneum is repaired to restore its natural water absorption capacity. 2. Moisturizing effect allantoin can promote the water absorption capacity of the outermost layer of skin and hair, reduce the evaporation of skin moisture, and form a layer of lubricating film on the skin surface, closed moisture, so as to achieve the role of skin moisturizing. 3, softening keratin effect allantoin has a unique nature of dissolving keratin, so it has the role of softening keratin protein, it stripped the metabolic waste at the same time, the intercellular spaces are filled with water to bring the skin to a hydrated, shiny state. 4. Anti-inflammatory and antioxidant effects allantoin is a kind of amphoteric compound, which can combine with a variety of substances to form double salt, and has the effects of avoiding light, sterilization, preservation, pain relief and antioxidation, it is widely used as an additive for pescing cream, stinging liquid, shampoo, soap, toothpaste, shaving lotion, hair conditioner, astringent, anti-sweat deodorant lotion and the like. |
| Use | allantoin is an important fine chemical product, which is widely used in medicine, light industry, agriculture, in medicine: allantoin can promote cell growth, accelerate wound healing, soften keratin and other physiological functions, it is a good healing agent and anti-ulcer agent for skin wounds. It can be used to relieve and treat xerosis, scaly skin disease, skin ulcer, digestive tract ulcer and inflammation, and has good curative effect on osteomyelitis, diabetes, cirrhosis and acne. 2, in cosmetics: allantoin is a kind of amphoteric compounds, can combine a variety of substances to form a double salt, with light, sterilization, anti-corrosion, pain, anti-oxidation effect, can keep the skin moisture, moisturizing and soft, is a cosmetic effect additives such as beauty. allantoin has the effect of promoting the growth of endothelial cells and rapid wound healing. Used as an anti-ulcer drug, mixed with dry aluminum hydroxide gel, used for peptic ulcer and inflammation. The product can soften keratan, so that the skin to maintain moisture, moisture and soft, is a special additive cosmetics. Allantoic Mutual and its derivatives or many daily chemical products quality improvers, additives. Allantoin protein can be formulated as an anti-irritant, anti-dandruff, cleansing, and wound-healing scalp preparation, making hair soft, shiny and elastic. The product is a kind of amphoteric compounds, can be combined with a variety of substances in the form of double salt, with light, sterilization, anti-corrosion, pain, deodorization, antioxidant effect, so it is a daily chemical products, beauty cosmetics such as pastille cream, face cream, shampoo, soap, toothpaste, An additive such as a astringent solution, an antiperspirant deodorant detergent, and the like. Allantoin is also a Biochemical reagent. for skin care, oral products, anti-allergy, treatment of skin ulcers to promote wound healing and other effects widely used in a variety of skin ulcers, cosmetic additives for the treatment and nutrition of wounds effective biomarkers for oxidative stress reactions; Mannich bases for synthesis as antibacterial agents; used in the synthesis of sulfonylchlorophenylurea analogs as antitumor agents; Used as plant growth regulators has amphoteric properties, can form metal salts and adducts with many substances and can maintain the original characteristics. The saturated aqueous solution (0.6%) is slightly acidic (pH = 6), which can remain stable in the aqueous solution of pH = 4~9, and decomposition occurs when boiling in alkaline solution for a long time. The pH of the saturated aqueous solution was 5.5. purine metabolites through the uric acid pathway. Uric acid can also react with free radicals to produce allantoin, thus allantoin can be used as an effective biomarker for oxidative stress. |
| Anti-inflammatory analgesic effect | allantoin has anti-inflammatory analgesic effect, and it also has weak local paralysis effect, can effectively reduce the stimulation of irritants, can be used as a skin protective agent and anti-irritant, can reduce the irritation of cosmetic ingredients to the skin, the Chinese Food and Drug Administration listed it as the first type of efficient active component skin care agent, which has been widely used in shampoo, sunscreen products, cream lotion, shaving cream and oral care products. |
CAS:
97-59-6
MF:
C4H6N4O3
MW:
158.12
EINECS:
202-592-8
MDL No.:
MFCD00005260
Melting point:
230 °C (dec.) (lit.)
Boiling point:
283.17°C (rough estimate)
Density
1.6031 (rough estimate)
refractive index
1.8500 (estimate)
Flash point:
230-234°C
storage temp.
2-8°C
solubility
H2O: soluble0.1g/10 mL, clear, colorless
pka
8.96(at 25℃)
form
Powder
color
White
Odor
odorless, tasteless
Water Solubility
Slightly soluble in water. Freely soluble in alkalis
Decomposition
230-234 ºC
Merck
14,258
BRN
102364
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
POJWUDADGALRAB-UHFFFAOYSA-N
LogP
-2.26 at 20℃
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.