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CAS NO.94-09-7
98%(500-1000)Kilogram98%(100-500)Metric Ton
| Molecular Formula | C9H11NO2 |
| Molar Mass | 165.19 |
| Density | 1.17 |
| Melting Point | 88-90°C |
| Boling Point | 172 °C (12.7517 mmHg) |
| Flash Point | 172°C/13mm |
| Water Solubility | Soluble in ethanol, chloroform, ethyl ether and dilute acids. Sparingly soluble in water |
| Solubility | alcohol: soluble1 gm in 5 ml |
| Vapor Presure | 0.000589mmHg at 25°C |
| Appearance | Crystalline Powder |
| Color | White |
| Merck | 14,1086 |
| BRN | 638434 |
| pKa | 2.5(at 25℃) |
| Storage Condition | 2-8°C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.5600 (estimate) |
| Physical and Chemical Properties | Density 1.17 melting point 89-92°C boiling point 172°C (17 torr) |
| Use | For cosmetics UV absorption, local anesthetics, for wounds, ulcers and hemorrhoids pain |
| Introduction | benzocaine is a white needle-like crystal with a melting point of 90-92 ℃, which is slightly soluble in water and easily soluble in organic solvents. Such as: ethanol, chloroform, ether, soluble in almond oil, olive oil. Benzocaine, as a non-water-soluble local anesthetic, has analgesic and antipruritic effects. It is clinically used for wound anesthesia, ulcer surface anesthesia, mucosal surface anesthesia and hemorrhoid anesthesia, its pharmacological action is mainly to block the nerve endings, in order to relieve pain and itching. |
| properties | benzocaine is a white needle-like crystal with a melting point of 90-92 ℃, slightly soluble in water and easily soluble in organic solvents. Such as: ethanol, chloroform, ether, soluble in almond oil, olive oil. |
| pharmacological action | benzocaine has weaker local anesthetic effect than procaine, which is not infiltrative and locally absorbed slowly and permanently. Hydrolysis to p-aminobenzoic acid has no irritation and toxicity at normal use concentrations of 2% to 10%, and the toxicity is only 5% or 10% of that of cocaine. The maximum safe amount for local use is 5g or 25 mL of 20% solution. It inhibits the conduction of nerves Impulse from sensory nerve endings, blurs the taste and is similar in structure to procaine, so it is slowly absorbed and the anesthetic effect is long-lasting. |
| Clinical application | benzocaine, as a non-water-soluble local anesthetic, has analgesic and antipruritic effects, ulcer surface anesthesia, mucosal surface anesthesia and hemorrhoids anesthesia, its pharmacological effects are mainly to block the nerve endings, to relieve pain and itching. |
| adverse reactions | benzocaine may cause allergic reactions. The positive reaction rate of patients with benzocaine patch test is 3.3% ~ 5.9%. Occasional dizziness, Nausea, local or systemic allergic reactions, such as rash, urticaria, edema and so on. |
| fat-soluble surface anesthetic | benzocaine is a fat-soluble surface anesthetic, compared with dicaine and the like, its action intensity is small, so that it does not cause discomfort due to the anesthetic effect when acting on the mucosa. It is a kind of drug with strong fat solubility, so it is easy to combine with the lipid layer of mucosa or skin, but it is not easy to penetrate into human body to produce toxicity. benzocaine can be used as a precursor raw material of osorbide, osocaine, procaine, etc. At the same time, it is also used as a local anesthetic in medicine, with analgesic and antipruritic effects, mainly used for wound, ulcer surface, mucosal surface and hemorrhoids anesthesia pain and itching disease, the ointment can also be used as nasopharyngeal catheter, endoscope and other lubrication pain relief. Temporarily relieves pain and itching skin discomfort, mild burns, sunburn, trauma and insect bites. Otic preparations are used to relieve the pain and itching of acute congestive, otitis externa, swimming otitis, and topical ear. Toothache, Laryngalgia, mouth ulcers, various hemorrhoids, anal fissure, genital itching is effective, as a male genital desensitizing agent to slow ejaculation. Or used as an anesthetic lubricant for catheters and endoscopic tubes. |
| Use | This product is a local anesthetic for the pain relief of wounds, ulcers and hemorrhoids, it is also an intermediate of antitussive drug cough. used for ultraviolet absorption in cosmetics, local anesthetics, for pain relief of wounds, ulcers and hemorrhoids |
| production method | from the reduction of P-nitrobenzoic acid ethyl ester [99-77-4] iron powder. |
CAS:
94-09-7
MF:
C9H11NO2
MW:
165.19
EINECS:
202-303-5
MDL No.:
MFCD00007892
Melting point:
88-90 °C
Boiling point:
172 °C (12.7517 mmHg)
Density
1.17
refractive index
1.5600 (estimate)
Flash point:
172°C/13mm
storage temp.
2-8°C
solubility
alcohol: soluble1 gm in 5 ml
pka
2.5(at 25℃)
form
Crystalline Powder
color
White
Odor
odorless
Water Solubility
Soluble in ethanol, chloroform, ethyl ether and dilute acids. Sparingly soluble in water
Merck
14,1086
BRN
638434
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
BLFLLBZGZJTVJG-UHFFFAOYSA-N
LogP
1.860
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.