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CAS NO.859-18-7
98%(500-1000)Kilogram98%(100-500)Metric Ton
Lincocin Hydrochloride
CAS: 859-18-7
Molecular Formula: C18H35ClN2O6S
| Name | Lincocin Hydrochloride |
| Synonyms | U-10149A LINCOMYCIN HCL Lincomycin Hcl Lincocin Hydrochloride LINCOCIN HYDROCHLORIDE lincomycin hydrochloride LINCOMYCIN HYDROCHLORIDE lincomycin standard solution Lincomycin hydrochloride anhydrous N-[2-HYDROXY-1-(3,4,5-TRIHYDROXY-6-METHYLSULFANYL-OXAN-2-YL)-PROPYL]-1-METHYL-4-PROPYL-PYRROLIDINE-2-CARBOXAMIDE methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride METHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO)-1-THIO-D-ERYTHRO-ALPHA-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE ALPHA-METHYL-6,8-DIDEOXY-6-[1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO]-1-THIO-D-ERYTHRO-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE |
| CAS | 859-18-7 |
| EINECS | 212-726-7 |
| InChI | InChI=1/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14+,15-,16-,18-;/m1./s1 |
| InChIKey | POUMFISTNHIPTI-BOMBIWCESA-N |
| Molecular Formula | C18H35ClN2O6S |
| Molar Mass | 443 |
| Melting Point | 156-158C |
| Boling Point | 646.8°C at 760 mmHg |
| Flash Point | 345°C |
| Water Solubility | Soluble in water. |
| Solubility | H2O: 50mg/mL, clear, colorless |
| Vapor Presure | 1.85E-19mmHg at 25°C |
| Appearance | solid |
| Color | white to white with yellow cast |
| BRN | 4171650 |
| Storage Condition | 2-8°C |
| Stability | Hygroscopic |
| MDL | MFCD00058237 |
| Use | Linamycin is an antibiotic that forms cross-links in the peptide-based transferase cyclic region of 23S rRNA and inhibits bacterial protein synthesis. |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 2 |
| RTECS | RH6315000 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29419000 |
| Reference
Show more |
1. He Pinjing, Guan Dongxing, Wu duo, et al. Inhibitory effect of ammonia nitrogen and lincomycin on anaerobic digestion... |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | lincomycin hydrochloride is used for semi-synthetic preparation of clindamycin, a semi-synthetic chlorinated derivative of lincomycin, it is suitable for various infectious diseases caused by gram-positive bacteria and anaerobic bacteria, and can also be used for the treatment of infections caused by methicillin-resistant Staphylococcus aureus. |
| characteristics | clindamycin hydrochloride is considered as one of the 20 most important antibiotics due to its strong anti-infection ability and wide therapeutic range. Structurally, lincomycin hydrochloride is modified by two parts of Lincosamide (LSM) and Propylproline (PPL). In recent years, the research on the biosynthesis mechanism of lincomycin has made substantial achievements, and the biosynthetic pathway has become increasingly clear. |
| antibiotics | lincomycin hydrochloride also known as clindamycin hydrochloride, jiminlike, lincomycin, lincomycin, linkenamycin hydrochloride is a white crystalline powder at room temperature, with slight or special odor, bitter taste, soluble in water or methanol, and its hydrochloride form is commonly used in feed. The drug is the product of the growth of the Streptomyces Streptomyces C. Nensis flora, which is a lincoamine alkaline antibiotic, which acts on the 50s subunit of the ribosome of sensitive bacteria, prevents the extension of the peptide chain, thereby inhibiting the protein synthesis of bacterial cells, has a bacteriostatic effect, but also has a bactericidal effect on highly sensitive bacteria at high concentrations. The antibacterial spectrum is the same as that of lincomycin, but the antibacterial activity is strong, oral absorption is fast and complete (about 90%), and eating has little effect on absorption. Lincomycin hydrochloride has strong antibacterial effect on Gram-positive bacteria, some anaerobic bacteria and mildew, and its antibacterial spectrum is narrower than erythromycin. Staphylococcus aureus, hemolytic Streptococcus, Pneumonia coccus and pig Pneumonia mildew body, chicken blood mold body is sensitive to this product, but Enterococcus is generally resistant to this product; Anaerobic bacteria such as Bacteroides, tetanus bacilli, clostridium, Clostridium perfringens, digestive cocci are also sensitive to this product. Mainly used in the treatment of gram-positive bacteria, especially penicillin-resistant gram-positive bacteria caused by a variety of infections, mildew-caused poultry chronic respiratory disease, pig asthma, anaerobic infections such as chicken necrotic enteritis, etc, it is also used in the treatment of swine Treponema dysentery, toxoplasmosis and actinomycosis in dogs and cats. The effect of lincomycin hydrochloride on septicemia caused by most Gram-negative bacteria and some anaerobic bacteria, female genital tract, endometritis, nongonococcal tubal ovarian abscess, pelvic cellulitis, postoperative vaginal adnexal infection, peritonitis, abscess, Pneumonia, lung abscess, skin and soft tissue infections have a therapeutic effect. Also used for Streptococcus and Staphylococcus caused by sepsis, bone and joint infection, chronic bone and joint infection of surgical adjuvant therapy, Staphylococcus caused by acute hematogenous osteomyelitis. But this product can not penetrate into the cerebrospinal fluid, it is not suitable for the treatment of meningitis. Topical treatment of gram-positive bacteria purulent infection. |
| Clinical application | 1. Oral preparation is suitable for the treatment of sensitive Staphylococcus, Streptococcus, Pneumonia coccus and anaerobic bacteria caused by respiratory tract infection, abdominal infection, female reproductive tract infection, pelvic infection, skin and soft tissue infection. 2. In addition to the above-mentioned infections, injectable preparations can be used to treat serious infections caused by Streptococcus, Pneumonia coccus and Staphylococcus, such as septicemia, bone and joint infections, surgical adjuvant therapy for chronic bone and joint infections, acute Hematogenous Osteomyelitis caused by Staphylococcus. 3. Lincomycin hydrochloride can also be used for the treatment of infectious diseases that are allergic to penicillin or are not suitable for use with penicillin drugs. tablets: 0.25g,0.5g per tablet; Injection: 0.2g,0.6g per tablet. |
| biological activity | Lincomycin hydrochloride (NSC 70731) is a salt of Lincomycin, they are substances produced by the growth of members of the genus Streptomyces. |
| Use | linkenamycin is an antibiotic that forms cross-links in the peptidyl transferase cyclic domain of 23S rRNA, inhibition of bacterial protein synthesis. |
Mol Download Chemical properties
CAS:
859-18-7
MF:
C18H35ClN2O6S
MW:
443
EINECS:
212-726-7
MDL No.:
MFCD00083647
Melting point:
156-158C
storage temp.
2-8°C
solubility
H2O: 50 mg/mL, clear, colorless
form
solid
color
white to white with yellow cast
Water Solubility
Soluble in water.
BRN
4171650
Stability:
Hygroscopic
InChIKey
POUMFISTNHIPTI-BOMBIWCESA-N
SMILES
[C@]([H])([C@]1([H])[C@@H]([C@H](O)[C@@H](O)[C@@H](SC)O1)O)([C@H](O)C)NC([C@H]1N(C[C@H](CCC)C1)C)=O.Cl |&1:0,2,4,5,7,9,14,19,22,r|
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
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