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CAS NO.77591-33-4
98%(500-1000)Kilogram98%(100-500)Metric Ton
Thymosin beta 4 acetate
CAS: 77591-33-4
Molecular Formula: C212H350N56O78S
| Name | Thymosin beta 4 acetate |
| Synonyms | Fx Peptide Thymosin β4 Thymosin beta4 Thymosin Beta 4 Thymosin beta(4) Thymosin β4 Acetate THYMOSIN SS4 ACETATE Thymosin beta 4 acetate thymosin beta 4 acetate Thymosin Beta4 Beta4 Acetate FX (HUMAN, BOVINE, HORSE, RAT) THYMOSIN BETA4 (HUMAN, BOVINE, HORSE, RAT) AC-SER-ASP-LYS-PRO-ASP-MET-ALA-GLU-ILE-GLU-LYS-PHE-ASP-LYS-SER-LYS-LEU-LYS-LYS-THR-GLU-THR-GLN-GLU-LYS-ASN-PRO-LEU-PRO-SER-LYS-GLU-THR-ILE-GLU-GLN-GLU-LYS-GLN-ALA-GLY-GLU-SER-OH |
| CAS | 77591-33-4 |
| EINECS | 1592732-453-0 |
| InChI | InChI=1/C212H350N56O78S/c1-16-106(7)166(261-190(323)131(64-75-160(292)293)231-172(305)109(10)228-174(307)134(78-91-347-15)245-196(329)140(98-165(302)303)255-201(334)147-53-39-88-266(147)209(342)135(52-29-38-87-221)250-197(330)139(97-164(300)301)254-198(331)143(100-269)229-113(14)276)204(337)246-129(62-73-158(288)289)187(320)233-118(47-24-33-82-216)179(312)252-137(94-114-42-19-18-20-43-114)194(327)253-138(96-163(298)299)195(328)237-121(50-27-36-85-219)181(314)258-144(101-270)199(332)239-119(48-25-34-83-217)178(311)251-136(92-104(3)4)193(326)236-116(45-22-31-80-214)175(308)235-122(51-28-37-86-220)189(322)263-168(110(11)273)207(340)249-133(66-77-162(296)297)192(325)264-169(111(12)274)206(339)248-126(58-69-152(224)279)184(317)243-128(61-72-157(286)287)186(319)234-120(49-26-35-84-218)180(313)256-142(95-153(225)280)211(344)268-90-40-54-148(268)202(335)257-141(93-105(5)6)210(343)267-89-41-55-149(267)203(336)259-145(102-271)200(333)238-117(46-23-32-81-215)177(310)244-132(65-76-161(294)295)191(324)265-170(112(13)275)208(341)262-167(107(8)17-2)205(338)247-130(63-74-159(290)291)188(321)241-125(57-68-151(223)278)183(316)242-127(60-71-156(284)285)185(318)232-115(44-21-30-79-213)176(309)240-124(56-67-150(222)277)173(306)227-108(9)171(304)226-99-154(281)230-123(59-70-155(282)283)182(315)260-146(103-272)212(345)346/h18-20,42-43,104-112,115-149,166-170,269-275H,16-17,21-41,44-103,213-221H2,1-15H3,(H2,222,277)(H2,223,278)(H2,224,279)(H2,225,280)(H,226,304)(H,227,306)(H,228,307)(H,229,276)(H,230,281)(H,231,305)(H,232,318)(H,233,320)(H,234,319)(H,235,308)(H,236,326)(H,237,328)(H,238,333)(H,239,332)(H,240,309)(H,241,321)(H,242,316)(H,243,317)(H,244,310)(H,245,329)(H,246,337)(H,247,338)(H,248,339)(H,249,340)(H,250,330)(H,251,311)(H,252,312)(H,253,327)(H,254,331)(H,255,334)(H,256,313)(H,257,335)(H,258,314)(H,259,336)(H,260,315)(H,261,323)(H,262,341)(H,263,322)(H,264,325)(H,265,324)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,290,291)(H,292,293)(H,294,295)(H,296,297)(H,298,299)(H,300,301)(H,302,303)(H,345,346) |
| Molecular Formula | C212H350N56O78S |
| Molar Mass | 4963.4408 |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Use | Cornea, skin repair, etc |
| Overview | thymic β4 is a member of the Thymosin β family. Thymic β4 is composed of 43 amino acids and is hydrophilic. |
| Application prospect | The latest research shows that the expression level of β4 gene in thymus acetate is positively correlated with cancer cell metastasis, it is closely related to tumor apoptosis. This provides a new way to find a new method for the treatment of cancer, so it has a broad prospect for the development of new drugs. |
| biological function and mechanism of action | Tβ4 is one of the main actin regulatory molecules in human body, which has multiple biological functions, in tissue regeneration, remodeling, wound healing, maintaining the balance of actin, tumor pathogenesis and metastasis, apoptosis, inflammation, angiogenesis, hair follicle development and other physiological, pathological process plays a very important role. 1. Actin regulatory factors actin accounts for about 10% of the total protein in non-muscle cells and is an important component of cell structure, cell movement and wound healing. Tβ4 in the cell is sufficient to block all actin and may be involved in the regulation of actin polymerization and depolymerization. Tβ4 can bind to actin monomer in a ratio of 1:1 to prevent the formation of F-actin aggregates, its C- terminus binds to actin His-40, resulting in a change in actin monomer conformation. Tβ4 molecular structure contains an actin binding domain (LKKTET), which is the main electrostatic contact site, and its N-terminal fragment can inhibit actin polymerization through steric hindrance, when acting alone, Tβ4 can inhibit actin polymerization and actin nucleoside exchange, which is contrary to the role of another actin binding protein Profiling, the latter can promote the exchange of ADP and ATP, accelerate the assembly of actin, Tβ4 and Profiling can coordinate the regulation of actin assembly. Tβ4 can regulate the transformation between G-actin and F-actin. It has been reported that in highly mobile blood cells, the concentration of Tβ4 reaches 300pmol, while the concentration required for binding of Tβ4 to G-actin is less than 20pmol; When the concentration is increased, tβ4 reduces the depolymerization ability of F-actin, which may be the reason why Tβ4 has the function of regulating the intracellular microfilament system. |
| Use | thymus acetate β4 has the following uses: 1. Thymic β4 and tumor studies have shown that thymic β4 acetate is associated with a variety of tumors, including colon cancer, melanoma, fibrosarcoma, breast cancer, pancreatic cancer and lung cancer, it can cooperate with a variety of factors to promote tumor invasion and metastasis. 2. The role of thymic β4 in the repair of cardiac injury in the acute phase of myocardial infarction, a large number of myocardial cell ischemic necrosis, resulting in impaired cardiac function, and ultimately progress to heart failure. Studies have confirmed that thymic acetate β4 can protect myocardial cells. |
Mol Download Chemical properties
CAS:
77591-33-4
MF:
C212H350N56O78S
MW:
4963.4408
EINECS:
1592732-453-0
MDL No.:
MFCD00082073
storage temp.
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Water Solubility
Water : 50 mg/mL (10.07 mM; Need ultrasonic)
InChIKey
UGPMCIBIHRSCBV-XNBOLLIBSA-N
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
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