Keywords

• Ursolic acid
• 77-52-1
• Rosemary Extract

Quick Details

• ProName: Top Quality Natural Ursolic acid Rosem...
• CasNo: 77-52-1
• Molecular Formula: C30H48O3
• Appearance: white powder
• Application: Pharmaceutical;Food Preservative;Cosme...
• DeliveryTime: 7-10 days
• PackAge: 1kg/bag,5kg/bag,25kg/drum
• Port: Beijing,Shanghai
• ProductionCapacity: 5000 Kilogram/Month
• Purity: 99%
• Storage: in a cool&dry place
• Transportation: By air,By Sea
• LimitNum: 1 Kilogram
• Plant of Origin: rice bran extract
• Testing Method: HPLC
• Product Ecification: 98%
• Heavy Metal: EP standards
• Voluntary Standards: EP standards

Superiority

77-52-1 - Physico-chemical Properties

77-52-1 - Introduction

Open Data Unverified Data

ursolic acid, also known as ursolic acid and ursolic acid, is a kind of pentacyclic triterpenoid compound extracted from the bear fruit of Evergreen, in absolute ethanol, large, shiny prisms are obtained, while in dilute ethanol, wool-like needles are obtained. mp285 ℃ ~ 288 ℃,[α]D20 66 ° (pyridine), soluble in dioxane, pyridine, soluble in methanol, ethanol, butanol, butanone, slightly soluble in acetone, slightly soluble in benzene, chloroform, ether, insoluble in water and petroleum ether. With sedation, anti-inflammatory, antibacterial, anti-diabetic, anti-ulcer, lower blood sugar and other biological effects. In recent years, it has been found that it has the effects of anti-carcinogenic, anti-promoting cancer, inducing F9 teratoma cell differentiation and anti-angiogenesis. It is very likely to become a new anti-cancer drug with low toxicity and high efficiency. In addition, ursolic acid has obvious antioxidant function and is a strong antioxidant. The antioxidant effect of ursolic acid has a positive effect on the anti-aging, skin freckle and pigment removal of human body, therefore, it is widely used as a raw material for medicine and natural whitening cosmetics. Experiments show that ursolic acid can inhibit the activity of 5-lipoxygenase and cyclooxygenase in the metabolism of arachidonic acid and prevent the formation of prostaglandins and leukotrienes, this may be the reason why ursolic acid inhibits inflammatory reaction and inhibits lipid peroxide.

Last Update：2022-01-01 08:50:12

77-52-1 - Physical properties

Open Data Unverified Data

high content of ursolic acid is glossy prismatic (absolute ethanol) or fine hair-like needle-like crystals (dilute ethanol), low content is Brown yellow or yellow green powder, with special odor, it is a pentacyclic triterpenoid found in natural plants. Melting point 283-288 ° C. Specific optical rotation [α]D25 +67.5 °(C = 1,1mol/L potassium hydroxide in alcoholic solution). At 15 ° C, ethanol (99%)1 mL can dissolve 10 mg, boiling 1 mL can dissolve 45 mg. Soluble in methanol, acetone, pyridine, insoluble in water and petroleum ether.

detection condition

• in order to better separate ursolic acid and oleanolic acid, the chromatographic column of a famous foreign company should be used, and the reason for the company in the production process is summarized.
• using Agilent C18 column, with acetonitrile: water (volume ratio 93:7) solution as mobile phase, with UV detector at 210Nm. Ethanol dissolved, standard dissolved 8-12mg/25m.

Production Process Flow

The crushed leaves of Eriobotrya japonica or ligustrum lucidum were extracted by ethanol reflux to obtain a liquid extract, and the ethanol was recovered. The above extracts were fully washed with water and dried to obtain a dry extract, dry extract is dissolved with ethanol and then decolorized. The decolorized solution is recovered by adding water to precipitate a large amount of precipitate after ethanol is recovered. The pH value is adjusted to 2-2.5, the main component of the crude extract was ursolic acid.

Details

Ursolic acid

CAS:

77-52-1

MF:

C30H48O3

MW:

456.71

EINECS:

201-034-0

MDL No.:

MFCD00009621

Properties

Melting point:

292 °C (dec.) (lit.)

alpha 

59 º (c=0.3, pyridine)

Boiling point:

502.79°C (rough estimate)

Density 

1.0261 (rough estimate)

refractive index 

1.4940 (estimate)

storage temp. 

2-8°C

solubility 

Soluble in DMSO (up to 25 mg/ml with warming)

form 

Crystalline Powder or Needles

pka

4.68±0.70(Predicted)

color 

White to off-white

Water Solubility 

insoluble

Merck 

14,9890

BRN 

2228563

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

LogP

8.731 (est)