Xi`an Eastling Biotech Co., Ltd.
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Province/state: Shaanxi
City: Xi'an city
Street: No. 201, Unit 4, Building 9, Hongqi Community, Tanjia Street, Weiyang District, Xi 'an, Shaanxi
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CAS NO.71939-50-9
98%(1-25)Kilogram98%(26-500)Kilogram98%(501-1000)Kilogram
Dihydroartemisinin
CAS: 81496-81-3;71939-50-9;123930-80-3
Molecular Formula: C15H24O5
| Molecular Formula | C15H24O5 |
| Molar Mass | 284.35 |
| Density | 1.24±0.1 g/cm3(Predicted) |
| Melting Point | 142-144°C |
| Boling Point | 375.6±42.0 °C(Predicted) |
| Specific Rotation(α) | +129 (c, 0.92 in CHCl3) |
| Flash Point | 181°C |
| Solubility | Easily soluble in chloroform, dissolved in acetone, slightly soluble in methanol or ethanol, almost insoluble in water. |
| Vapor Presure | 3.52E-07mmHg at 25°C |
| Appearance | White needle crystal |
| Color | White to Off-White |
| pKa | 12.61±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.542 |
| MDL | MFCD00274495 |
| Physical and Chemical Properties | White needle Crystal, odorless, bitter taste. It is soluble in chloroform and soluble in acetone. Slightly soluble in methanol or ethanol, almost insoluble in water. The melting point was 145-150 °c. |
| Reference
Show more |
1. Zhu Chunyan, Xu Qiong, Mao Zhiyun, etc. Comparison of effects of three artemisinin derivatives on pain co-emotion dis... |
| Use | dihydroartemisinin can be used in a variety of malaria, especially for anti-chloroquine, treatment of falciparum malaria and dangerous cerebral malaria. |
| medicinal properties and application | dihydroartemisinin has a strong killing effect on asexual bodies of Plasmodium falciparum, it can quickly control the symptoms and kill the various forms of the malaria parasite in the vegetative period, and it is also effective for chloroquine and piperaquine resistant falciparum malaria, and the toxicity is low. Animal experiments have found that administration in the induction phase of pregnancy in mice can increase the occurrence of fetal absorption, but no teratogenic effect. Oral absorption, oral administration of this product 2 mg/kg,tmax 1.33h,Cmax 0.71 μg/ml. Clinical for various types of malaria, especially for chloroquine, piperaquine-Resistant Brain, dangerous disease of falciparum malaria rescue. |
| adverse reactions | There was a transient decrease in peripheral reticulocytes and white blood cells, and elevated transaminase. Dihydroartemisinin piperaquine has Nausea, Vomit, Abdominal Pain, Diarrhea and loss of appetite, etc., as well as dizziness, Head Pain, rash, skin itching and so on. |
| principle of action | dihydroartemisinin is a derivative of artemisinin. Has a strong killing effect on the parasite asexual body, can quickly control the symptoms, and kill the protozoa, against chloroquine, Piva falciparum equally effective. |
| contraindication | is contraindicated for those allergic to this product. Severe liver and kidney disease, blood diseases, the first 3 months of pregnancy disabled Dihydroartemisinin and Piperaquine Phosphate Tablets. |
| precautions | should be used with caution during pregnancy; Dihydroartemisinin and Piperaquine Phosphate Tablets has a long half-life, and should not be used repeatedly within half a month. |
Mol Download Chemical properties
CAS:
71939-50-9
MF:
C15H24O5
MW:
284.35
EINECS:
MDL No.:
MFCD18323866
Melting point:
144-149°C
Boiling point:
375.6±42.0 °C(Predicted)
Density
1.24
storage temp.
Inert atmosphere,2-8°C
solubility
DMSO : 41.67 mg/mL (146.54 mM; Need ultrasonic)
pka
12.61±0.70(Predicted)
form
solid
color
White to Almost white
Merck
14,817
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.