Xi`an Eastling Biotech Co., Ltd.
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China (Mainland)
Business Type:Lab/Research institutions
Tel: +86-156-91766041
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Tel: +86-156-91766041
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URL: http://www.eastlingbiotech.com/
Province/state: Shaanxi
City: Xi'an city
Street: No. 201, Unit 4, Building 9, Hongqi Community, Tanjia Street, Weiyang District, Xi 'an, Shaanxi
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CAS NO.6754-58-1
98%(1-25)Kilogram98%(26-500)Kilogram98%(501-1000)Kilogram
| Molecular Formula | C21H22O5 |
| Molar Mass | 354.4 |
| Density | 1.244 |
| Melting Point | 157-159℃ |
| Boling Point | 576.5±50.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| Appearance | Orange powder |
| Color | Yellow |
| pKa | 7.59±0.45(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| MDL | MFCD00210576 |
| Physical and Chemical Properties | Character: light yellow crystal extraction Source: antioxidant substances extracted from hops A substance called xanthohumol in hops has attracted more and more attention, this substance belongs to isopentene flavonoid compound (xantho-humol, xn for short), and the research of scientists shows that Xanthohumol has obvious anti-cancer effect. Professor Fang Jianguo, State Key Laboratory of functional organic molecular chemistry, Lanzhou University, found that an active molecule contained in beer called xanthohumol could help the brain fight Parkinson's disease and Alzheimer's disease the violation of neurodegenerative diseases, become the focus and hot spot of the world's major media reports in early 2015. |
| In vitro study | In the culture medium of mouse hepatoma cells, Xanthohumol inhibited Cyp1A activity and induced QR activity. Xanthohumol scavenges reactive oxygen species and inhibits superoxide anion groups and nitric oxide production. In addition, Xanthohumol prevents carcinogenesis by inhibiting DNA synthesis and inducing S-phase cell cycle arrest, apoptosis, and cell differentiation. Xanthohumol exhibits potent anti-HIV-1 activity. |
| In vivo study | In CETP-Tg mice, xanthohumol (p.o.) prevents atherosclerosis resulting from cholesterol accumulation. In TRAMP mice, Xanthohumol (p.o.) induces a decrease in the mean weight of the urogenital (UG) tract, delays advanced tumor progression, and inhibits the growth of poorly differentiated prostate cancer. |
CAS:
6754-58-1
MF:
C21H22O5
MW:
354.4
EINECS:
614-078-4
MDL No.:
MFCD00210576
Melting point:
157-159℃
Boiling point:
576.5±50.0 °C(Predicted)
Density
1.244
storage temp.
2-8°C
solubility
ethanol: soluble10mg/mL
form
powder
pka
7.59±0.45(Predicted)
color
Yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChI
InChI=1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+
InChIKey
ORXQGKIUCDPEAJ-YRNVUSSQSA-N
SMILES
C(C1=C(OC)C=C(O)C(C/C=C(/C)\C)=C1O)(=O)/C=C/C1=CC=C(O)C=C1
LogP
5.172 (est)
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.