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CAS NO.616204-22-9
98%(500-1000)Kilogram98%(100-500)Metric Ton
Argireline
CAS: 616204-22-9
Molecular Formula: C34H60N14O12S
| Name | Argireline |
| Synonyms | Reproage Argireline Anti-Wrinkle Multi-Peptides Ac-Glu-Glu-Met-Glu-Arg-Arg-NH2 Argireline,Acetyl hexapeptide-3, BR N-Acetyl-L-alpha-glutamyl-L-alpha-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-argininamide Argireline acetate Ac-Glu-Glu-Met-Arg-Arg-NH2 |
| CAS | 616204-22-9 |
| EINECS | 1592732-453-0 |
| InChI | InChI=1/C34H60N14O12S/c1-17(49)43-20(8-11-25(51)52)29(57)47-22(9-12-26(53)54)31(59)48-23(13-16-61-2)32(60)46-21(7-10-24(35)50)30(58)45-19(6-4-15-42-34(39)40)28(56)44-18(27(36)55)5-3-14-41-33(37)38/h18-23H,3-16H2,1-2H3,(H2,35,50)(H2,36,55)(H,43,49)(H,44,56)(H,45,58)(H,46,60)(H,47,57)(H,48,59)(H,51,52)(H,53,54)(H4,37,38,41)(H4,39,40,42)/t18-,19-,20-,21-,22-,23-/m0/s1 |
| InChIKey | RJZNPROJTJSYLC-LLINQDLYSA-N |
| Molecular Formula | C34H60N14O12S |
| Molar Mass | 889 |
| Density | 1.54 |
| Solubility | water soluble |
| Appearance | lyophilized solid |
| Color | white |
| pKa | 4.43±0.10(Predicted) |
| Storage Condition | -20°C |
| Refractive Index | 1.66 |
| In vitro study | The incubation of Argireline solution in different concentrations with human embryonic kidney HEK-293 (IC 50 of 34.862 μM) and neuroblastoma IMR-32 cells (IC 50 of 68.458 μM)) for 48 h have dose dependent antiproliferative effect. Argireline solution incubated in different concentrations with HSF has a dose-dependent antiproliferative effect on those cells. Cellular proliferation is not effected in Argireline low concentration. |
| In vivo study | Argireline is applied to the aged mice twice daily for 6 weeks. There is an improvement in the histological structure of skin tissue in the aged mice; the amount of type I collagen fibers increased, while that of type III collagen fibers decreased. Argireline could improve the histological structure of skin tissue and rejuvenate the aging skin. |
| Introduction | Argireline, also known as Botox, it is an oligopeptide that mimics the N-terminal 6 amino acids of SNAP-25 protein. Akirelin is one of the commonly used raw materials for high-end cosmetics. The main effect is to reduce wrinkles caused by facial expression muscle contraction, and to have an ideal effect on removing wrinkles around the forehead or eyes. akirelin is a safer, cheaper and milder alternative to botulinum toxin. Akirelin participates in the competition of SNAP-25 in the site of the fusion vesicle complex, thus affecting the formation of the fusion vesicle complex, resulting in the vesicles can not effectively release neurotransmitters, so that muscle contraction is weakened, which can relax the muscles, soothing fine lines make the skin clear, can also promote cell regeneration to restore skin soft and elastic, so it is widely used in the preparation of cosmetics and health products. |
| Use | Argireline, also known as botulinum-like, it is an oligopeptide that mimics the N-terminal 6 amino acids of SNAP-25 protein. Akirelin is one of the commonly used raw materials for high-end cosmetics. The main effect is to reduce wrinkles caused by facial expression muscle contraction, and to have an ideal effect on removing wrinkles around the forehead or eyes. In addition, it can also promote the production of collagen, help skin tissue reconstruction. |
| effect | The sixth peptide, an oligopeptide mimicking the N-terminus of the SNAP-25 protein and consisting of six amino acids. By inhibiting the synthesis of SNARE acceptors, the six peptides inhibit the excessive release of catecholamines and acetylcholines in the skin, locally block the nerve to transmit muscle contraction signals, and relax the facial muscles, to achieve the purpose of smoothing fine lines. |
| preparation | A preparation method of akerelin, comprising the following steps: Step 1: taking resin, activating, amino Resin; Step 2: Take the amino resin obtained in step 1, the first step coupling guanidine protected L-arginine, guanidine protected L-arginine, side Chain Amino-protected L-glutamine to obtain tripeptide resin; Step 3: Take the tripeptide resin obtained in step 2, and gradually couple L-methionine, side chain carboxyl-protected L-glutamic acid, N-acetyl-L-glutamic acid protected by side chain carboxyl group to obtain hexapeptide resin; Step 4: cleave the hexapeptide resin obtained in step 3 to obtain the first product; Step 5: the first product obtained in step 4 is purified and obtained. |
| biological activity | Argireline (Acetyl hexapeptide-3) is a non-toxic, skin-permeable anti-wrinkle peptide. Argireline significantly inhibits Ca2 dependent neurotransmitter release at the neuromuscular junction. Argireline has anti-wrinkle and anti-aging effects. |
Mol Download Chemical properties
CAS:
616204-22-9
MF:
C34H60N14O12S
MW:
889
EINECS:
1592732-453-0
MDL No.:
MFCD09842097
Density
1.54
storage temp.
-20°C
solubility
water soluble
solubility
water soluble
form
lyophilized solid
pka
4.43±0.10(Predicted)
color
white
InChIKey
RJZNPROJTJSYLC-LLINQDLYSA-N
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.