Xi`an Eastling Biotech Co., Ltd.
Diamond Supplier
- Diamond
Supplier - 1st
years
Diamond Supplier
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Lab/Research institutions
Tel: +86-156-91766041
Mobile:
Tel: +86-156-91766041
Fax:
URL: http://www.eastlingbiotech.com/
Province/state: Shaanxi
City: Xi'an city
Street: No. 201, Unit 4, Building 9, Hongqi Community, Tanjia Street, Weiyang District, Xi 'an, Shaanxi
MaxCard:
Contact Suppliers
CAS NO.6119-47-7
98%(1-25)Kilogram98%(26-500)Kilogram98%(501-1000)Kilogram
Quinine monohydrochloride dihydrate
CAS: 6119-47-7
Molecular Formula: C20H27ClN2O3
| Name | Quinine monohydrochloride dihydrate |
| Synonyms | Quinine Monohy Quinine HCl Dihydrate Quinine monohydrochloride dihydrate QUININEHYDROCHLORIDE,DIHYDRATE,CRYSTAL (9R)-6'-methoxycinchonan-1'-ium-9-ol chloride dihydrate (8α, 9R)-6′-Methoxycinchonan-9-ol monohydrochloride dihydrate (4beta,8alpha,9R)-6'-methoxycinchonan-9-ol hydrochloride dihydrate Cinchonan-9-ol, 6-methoxy-, monohydrochloride, dihydrate, (8.alpha.,9R)- (R)(6-Methoxy-4-quinolyl)(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol hydrochloride (R)(6-methoxy-4-quinolyl)(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol monohydrochloride dihydrate |
| CAS | 6119-47-7 |
| EINECS | 612-097-2 |
| InChI | InChI=1/C20H24N2O2.ClH.2H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;2*1H2/t13 ,14 ,19 ,20-;;;/m1.../s1 |
| InChIKey | MPQKYZPYCSTMEI-HPVDNOPASA-N |
| Molecular Formula | C20H27ClN2O3 |
| Molar Mass | 378.9 |
| Melting Point | 115-116°C (dec.)(lit.) |
| Boling Point | 495.9°C at 760 mmHg |
| Specific Rotation(α) | [α]D20 -245～-255° (c=2, dil. HCl) (After Drying) |
| Flash Point | 122 °C |
| Water Solubility | Sparingly soluble in water.(0.26 g/L) (25°C), |
| Solubility | H2O: soluble0.25/5g/mL, clear, colorless |
| Vapor Presure | 1.19E-10mmHg at 25°C |
| Appearance | Crystalline Powder or Silky Needles |
| Color | White to off-white |
| Merck | 14,8061 |
| BRN | 6112655 |
| PH | 6.0 (10g/l, H2O, 20℃) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Sensitive | Light Sensitive |
| Refractive Index | -250 ° (C=2, EtOH) |
| MDL | MFCD00151248 |
| Use | K channel blocker. |
| In vitro study | Quinine blocked the Cx36 and Cx50 junction currents in a reversible and concentration-dependent manner, with half-maximal blocking concentrations of 32 mM and 73 mM, respectively. Quinine induces a slow transition between the open and fully closed states, which reduces the open probability of the channel. Quinine prevents certain types of gap junction channels, including those between neurons, from forming through CX36. Quinine, a K-channel blocker, prevents the formation of tumor necrosis factor (TNF) and subsequent liver DNA fragmentation and liver enzyme leakage. Quinine caused a Fos-like immune response (FLI) to concentrate in the medial third nucleus; Acid caused a more widespread FLI concentration more laterally. Quinine had a relatively weak effect on doxorubicin accumulation but completely restored doxorubicin sensitivity in resistant cells. Quinine also modified intracellular accumulation of doxorubicin, suggesting a modified intracellular drug distribution. Quinine predominantly blocks the voltage dependence in the whole-cell potassium current (IK). Quinine has also been used to dependently reduce sodium current (INa) while leaving calcium current (ICA) relatively unaffected. |
| FEMA | 2976 | QUININE HYDROCHLORIDE |
| appearance | White amorphous or crystalline powder |
| solubility | Water: 62.5g/l (20 C), soluble in ethanol, glycerol and chloroform, slightly soluble in ether. |
| Use | K channel blocker. |
| biological activity | Quinine HCl Dihydrate is a natural white crystalline alkaloid, with fever (heat), anti-malaria, analgesic, analgesic, anti-inflammatory properties, bitter taste. |
| Target | Value |
Last Update：2023-12-21 00:21:33
Solubility in water: 62.5g/l (20 C), soluble in ethanol, glycerol and chloroform, slightly soluble in ether.
Mol Download Chemical properties
CAS:
6119-47-7
MF:
C20H27ClN2O3
MW:
378.9
EINECS:
612-097-2
MDL No.:
MFCD00151248
Melting point:
115-116 °C (dec.)(lit.)
alpha
[α]D20 -245～-255° (c=2, dil. HCl) (After Drying)
FEMA
refractive index
-250 ° (C=2, EtOH)
Flash point:
122 °C
storage temp.
Keep in dark place,Inert atmosphere,2-8°C
solubility
H2O: soluble0.25/5g/mL, clear, colorless
form
Crystalline Powder or Silky Needles
color
White to off-white
PH
6.0 (10g/l, H2O, 20℃)
Odor
odorless
Odor Type
odorless
optical activity
[α]22/D 235°, c = 2 in 0.1 M HCl
Water Solubility
Sparingly soluble in water.(0.26 g/L) (25°C),
Sensitive
Light Sensitive
Merck
14,8061
BRN
6112655
InChIKey
MPQKYZPYCSTMEI-HPVDNOPASA-N
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.