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CAS NO.56-53-1
98%(500-1000)Kilogram98%(100-500)Metric Ton
Diethylstilbestrol
CAS: 56-53-1;6898-97-1
Molecular Formula: C18H20O2
| Name | Diethylstilbestrol |
| Synonyms | OeKolp NSC-3070 Atovaquone Oestromenin oestrolvetag Stilboestrol Oestrol vetag New-Estranol 1 neo-oestranol1 neo-oestranoli Diethylstilbestrol Diethylstilbestrol BP a,a-Diethyl-4,4-Stilbenediol Carc. 4,4'-(3Z)-hex-3-ene-3,4-diyldiphenol 4,4'-(3E)-hex-3-ene-3,4-diyldiphenol Diethylstilbestrol,mixture of cis and trans diethylstilbestrol, mixture of cis and trans |
| CAS | 56-53-1 6898-97-1 |
| EINECS | 200-278-5 |
| InChI | InChI=1/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17- |
| Molecular Formula | C18H20O2 |
| Molar Mass | 268.35 |
| Density | 1.1096 (rough estimate) |
| Melting Point | 170-172°C(lit.) |
| Boling Point | 351.51°C (rough estimate) |
| Flash Point | 187°C |
| Water Solubility | PRACTICALLY INSOLUBLE |
| Solubility | PRACTICALLY INSOLUBLE |
| Vapor Presure | 3.29E-07mmHg at 25°C |
| Appearance | Crystalline powder |
| Color | White to almost white |
| Merck | 13,3155 |
| BRN | 2056095 |
| pKa | pKa 9.02(H2O t=25 I=0.025) (Uncertain) |
| Storage Condition | 2-8°C |
| Stability | Isomerizes rapidly in Benzene, Chloroform, and Ether.Keep Shielded from light. |
| Refractive Index | 1.4800 (estimate) |
| MDL | MFCD00002373 |
| Use | Hormone drugs |
| pharmacological effects | Diethylstilbestrol is a synthetic non-steroidal estrogen, which can inhibit the secretion of pituitary gonadotropin, so as to change the hormone balance in the body, destroy the conditions of tumor tissue growth and development. |
| indication | diethylstilbestrol indication: 1. Supplement estrogen deficiency, such as atrophic vaginitis, female gonadal dysplasia, menopausal syndrome, senile vulvar dryness and vaginitis, after ovariectomy, primary ovarian deficiency; 2. Breast cancer, postmenopausal and male advanced breast cancer, can not be operated on; 3. Advanced prostate cancer, inoperable patients; 4. Prevention of postpartum lactation. |
| drug interaction | 1 when used with anticoagulants, estrogen can reduce the anticoagulant effect, anticoagulant dosage should be adjusted. 2 simultaneous use with carbamazepine, phenobarbital, phenytoin sodium, primidone, and rifampicin reduced the estrogenic effect due to induction of liver microsomal enzymes and increased estrogen metabolism. 3 with the simultaneous use of tricyclic antidepressants, a large amount of estrogen can enhance the adverse reactions of antidepressants, while reducing its due effect. 4 with antihypertensive drugs at the same time, can reduce the role of antihypertensive. 5 decreased the therapeutic effect of tamoxifen. 6 increased absorption of calcium. |
| Use | anabolic steroids, combined with potent estrogen activity, are carcinogenic. Diethylstilbestrol has also been used in animal production to accelerate its growth rate, and excessive residues of diethylstilbestrol in poultry or fish may cause harm to consumers. Therefore, diazepam has been banned from food production. The EU requires 2ppb as a positive lower limit. It is a hormone medicine, which is mainly used for functional bleeding and amenorrhea caused by estrogen deficiency and hormone imbalance. It can also be used before induced labor of dead fetus to improve the sensitivity of myometrium to oxytocin. synthetic estrogens with carcinogenic properties. Causes clear cell renal cell carcinoma in Syrian hamsters. In humans will result in increased breast cancer, clear cell adenocarcinoma of the vagina and cervix (CCA), and reproductive abnormalities. |
Mol Download Chemical properties
CAS:
56-53-1
MF:
C18H20O2
MW:
268.35
EINECS:
200-278-5
MDL No.:
MFCD00002373
Melting point:
170-172 °C(lit.)
Boiling point:
351.51°C (rough estimate)
Density
1.1096 (rough estimate)
refractive index
1.4800 (estimate)
storage temp.
2-8°C
solubility
methanol: 0.1 g/mL, clear, faintly yellow
form
Crystalline Powder
pka
pKa 9.02(H2O t=25 I=0.025) (Uncertain)
color
White to almost white
Water Solubility
PRACTICALLY INSOLUBLE
Merck
13,3155
BRN
2056095
Stability:
Isomerizes rapidly in Benzene, Chloroform, and Ether. Keep Shielded from light.
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.