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CAS NO.497-76-7
98%(1-25)Kilogram98%(26-500)Kilogram98%(501-1000)Kilogram
| Molecular Formula | C12H16O7 |
| Molar Mass | 272.25 |
| Density | 1.3582 (rough estimate) |
| Melting Point | 195-198°C |
| Boling Point | 375.31°C (rough estimate) |
| Specific Rotation(α) | -64 º (c=3) |
| Flash Point | 293.4°C |
| Water Solubility | 10-15 g/100 mL at 20 ºC |
| Solubility | Insoluble in chloroform, ether, petroleum ether, etc. |
| Vapor Presure | 1.9E-13mmHg at 25°C |
| Appearance | White needle crystal |
| Color | White |
| Merck | 14,773 |
| BRN | 89673 |
| pKa | 10.10±0.15(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Stable. Hygroscopic - store under dry nitrogen. |
| Sensitive | Hygroscopic |
| Refractive Index | -65.5 ° (C=4, H2O) |
| MDL | MFCD00016915 |
| Physical and Chemical Properties | Melting Point 198-201°C specific optical rotation -64 ° (c = 3) water-soluble 10-15g/100 mL at 20°C |
| Use | Medicine used as diuretics, urinary system anti-infective drugs, also used as color photography development stabilizer, used in cosmetics for whitening, freckle, hair care, etc |
| ideal whitening agent for whitening cosmetics | arbutin is also called arbutin, arbutin, arbutin, arbutin or myricin. because it originated from natural green plants, it is a skin whitening active substance integrating the concepts of "green", "safety" and "high efficiency. Arbutin is an ideal whitening agent for whitening cosmetics. There are two optical isomers, namely α and ß, and the β isomer with biological activity. It is white with light yellow powder at room temperature, easily soluble in water, methanol, ethanol, propylene glycol, glycerin aqueous solution, no precipitation solution after dissolution, and insoluble in chloroform, ether, petroleum ether, etc. It is added in many whitening products. It was named because it was found in the leaves of the bear fruit plant of the Rhododendron family, and later in the Vaccinium plant of the Rhododendron family, the pear tree (western pear, small mountain pear), and the leaves of the Saxifraga plant of the Saxifraga family. It was found in the leaves and used as a drug and cosmetic additive after extraction. arbutin is one of the safest and most effective whitening materials popular abroad at present, and it is also the most competitive skin whitening and freckle removing agent in the 21st century. In cosmetics, the skin can effectively whiten and remove freckle, gradually fade and remove freckles, chloasma, melanin, acne and age spots on the skin. High safety, no side effects such as irritation and sensitization, good compatibility with various components of cosmetics, and stable ultraviolet radiation. But arbutin is easy to hydrolyze and should be used under the condition of pH 5-7. In order to stabilize the performance, an appropriate amount of antioxidants such as sodium bisulfite and vitamin E are usually added to better realize whitening, freckle removal, moisturizing, softening, wrinkle removal and anti-inflammatory effects. It can be used to eliminate redness and swelling, promote wound healing without leaving scars, and inhibit the formation of dandruff. |
| ursolic acid and α-arbutin | ursolic acid is a triterpenoid compound existing in natural plants, which has sedative, anti-inflammatory, antibacterial, anti-diabetic, anti-ulcer, lowering blood sugar and other biological effects. In recent years, it has been found that it has anti-carcinogenic, anti-cancer, induction of F9 teratoma cell differentiation and anti-angiogenesis effects, and it is very likely to become a new anti-cancer drug with low toxicity and high efficiency. In addition, ursolic acid has obvious antioxidant function, so it is widely used as a raw material for medicine and cosmetics. α-arbutin can repair skin damage caused by ultraviolet rays, recall the skin's transparency, and is not easy to be decomposed by β-glucosidase on the skin surface. The effect is about 10 times that of β-arbutin. It can stay in every corner of the skin for a long time and continuously protect the skin from harm. Melanin is the cause of dull skin. α-arbutin can quickly penetrate deep into the skin and inhibit the activity of tyrosinase in pigment mother cells deep in the stratum corneum. And form a double effect on the skin surface to inhibit the production of melanin. |
| is it suitable for daytime use | arbutin reduces the production of melanin by inhibiting the activity of tyrosinase, an enzyme that produces melanin. its principle of action is similar to that of the whitening drug hydroquinone. However, hydroquinone has side effects and many precautions, which must be used under the guidance and monitoring of doctors. However, arbutin has more glucose molecules than hydroquinone in its structure, has lower irritation, and can be freely added to skin care products, with an upper concentration limit of 7%. The active molecule of arbutin can penetrate the basal layer for deep spot lightening. It has a strong therapeutic effect on chloasma, black spot, sunburn, and pigmentation left by drug allergy, but if the concentration is too low, its effect The persistence will be weakened, so 5% concentration is the safest and most efficient spot lightening concentration, 5% concentration is faster than vitamin C spot lightening effect, and the persistence of spot lightening is stable, it will not have an irritating effect on the skin. Arbutin will be reduced to hydroquinone after being absorbed by the skin, which has caused some people to doubt the safety of arbutin, and believe that arbutin still has a chance to produce side effects similar to hydroquinone. The most commonly heard saying is that "skin care products containing arbutin cannot be used during the day, otherwise whitening will not be achieved, but darker". in fact, there is no need to worry. tests show that only arbutin with a concentration of more than 7% is likely to be sensitive to light, so 7% is a safety critical point. there are clear regulations on the addition of ingredients in skin care products. the upper limit of the maximum concentration is 7%. within this concentration range, arbutin is not enough to produce photosensitivity and cannot be used without light. Absorbed by the skin and decomposed by light, it will be reduced to hydroquinone, resulting in a whitening effect. The concentration of hydroquinone contained in arbutin maintenance products is less than 20ppm (that is, 20 parts per million). Under such a low concentration limit, hydroquinone will not cause side effects such as skin blackening. If you dare not use arbutin during the day just because the care products contain arbutin, it is unnecessary, unless the care products containing arbutin are also added with other maintenance ingredients that need to avoid light. In short, you should buy reliable brand care products, and then no matter what you apply, you should do a good job of sunscreen during the day. |
| use | medically used as diuretics, urinary system anti-infective drugs, also used as color photography development stabilizer, used in cosmetics for whitening, freckle removal, hair care, etc. a glycosylated hydroquinone, used to study melatonin biosynthesis and as an inhibitor for identifying, distinguishing and identifying tyrosinase. Arbutin is a glycosylated hydroquinone extracted from bear fruit plants. Arbutin is a known tyrosinase inhibitor, which in turn prevents the formation of melanin. Arbutin is often used as a whitening agent for cosmetics. Inhibition of melanocyte tyrosinase activity, inhibition of melanin production by inhibiting melanin synthase. |
CAS:
497-76-7
MF:
C12H16O7
MW:
272.25
EINECS:
207-850-3
MDL No.:
MFCD00016915
Melting point:
195-198 °C
alpha
-64 º (c=3)
Boiling point:
375.31°C (rough estimate)
Density
1.3582 (rough estimate)
refractive index
-65.5 ° (C=4, H2O)
storage temp.
Inert atmosphere,Room Temperature
solubility
H2O: 50 mg/mL hot, clear
pka
10.10±0.15(Predicted)
color
White
optical activity
[α]/D -64.0±2.0°, c = 3 in H2O
Water Solubility
10-15 g/100 mL at 20 ºC
Sensitive
Hygroscopic
Merck
14,773
BRN
89673
Stability:
Stable. Hygroscopic - store under dry nitrogen.
InChIKey
BJRNKVDFDLYUGJ-RMPHRYRLSA-N
LogP
-1.350
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.