Keywords

• 489408-02-8
• YDL223C HBT1
• 1H-Pyrazole-1-acetamide

Quick Details

• ProName: Factory Supply YDL223C HBT1 99%
• CasNo: 489408-02-8
• Molecular Formula: C16H17F3N4O2S
• Appearance: White powder
• Application: Raw materials of Dietary Supplements
• DeliveryTime: 1-3days
• PackAge: 100 gram/ bag, 1kg/ bag, 25kgs/ drum?
• Port: China main port
• ProductionCapacity: 100 Metric Ton/Year
• Purity: 99.9%
• Storage: Store in tight, light-resistant contai...
• Transportation: By dhl fedex
• LimitNum: 1 Gram
• Heavy Metal: ≤10PPM
• Valid Period: 2 years
• PackAge:: 25kg per drum

Superiority

Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.

Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.

We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.

We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.

Details

HBT1 binds to the ligand-binding domain of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R) in a glutamate-dependent manner. This means that HBT1 is a molecule that can only bind to specific sites on the AMPA-R protein when glutamate is present, and that this binding helps regulate the protein's activity.  AMPA receptors are expressed throughout the central nervous system and play important roles in neuronal communication, sensory processing, and learning, memory, and synaptic plasticity.  AMPA receptors are major contributors to excitatory neurotransmission, mediate rapid, rapid desensitized excitation of many synapses, and are involved in early responses of synaptic regions to glutamate.  AMPA receptors are often coexpressed with NMDA receptors at synapses, and together they promote synaptic plasticity processes involved in learning, memory, excitotoxicity, and neuroprotection. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor that plays an important role in the maintenance and expansion of neurons, and has potent and numerous effects on the proliferation, differentiation, survival and death of neuronal and non-neuronal cells, Acts as a neurotransmitter modulator and contributes to neuronal plasticity for learning and memory. It is therefore essential to the health and well-being of the nervous system.  An increase in BDNF may prove helpful in the treatment and prevention of many diseases.

 HBT1 is a novel AMPA receptor enhancer with lower agonism compared with LY451395 and OXP1, it induces the production of brain-derived neurotrophic factor (BDNF), and it shows little effect in primary neurons Agitation.  HBT1 binds to the ligand-binding domain of AMPA-R in a glutamate-dependent manner. Together, they promote synaptic plasticity processes involved in learning, memory, excitability and neuroprotection. It can improve the cognitive ability and memory of the brain, and enhance people's learning ability.