Keywords

• Genistein
• 446-72-0
• Genistein powder

Quick Details

• ProName: Top Quality Natural Genistein 98%
• CasNo: 446-72-0
• Molecular Formula: C15H10O5
• Appearance: white powder
• Application: Pharmaceutical;Food Preservative;Cosme...
• DeliveryTime: 7-10 days
• PackAge: 1kg/bag,5kg/bag,25kg/drum
• Port: Beijing,Shanghai
• ProductionCapacity: 5000 Kilogram/Month
• Purity: 99%
• Storage: in a cool&dry place
• Transportation: By air,By Sea
• LimitNum: 1 Kilogram
• Plant of Origin: rice bran extract
• Testing Method: HPLC
• Product Ecification: 98%
• Heavy Metal: EP standards
• Voluntary Standards: EP standards

Superiority

Genistein

CAS: 446-72-0

Molecular Formula: C15H10O5

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446-72-0 - Names and Identifiers

446-72-0 - Physico-chemical Properties

• genistein is one of the main active factors in soybean isoflavones. It is the most effective functional component in Soybean isoflavone products and has a variety of physiological functions. Genistein is structurally similar to mammalian estrogen-estradiol and has a variety of physiological activities such as estrogenic activity because it has the active group of estrogen-diphenolic hydroxyl group.
• soybean isoflavones are a class of secondary metabolites formed in the growth of soybean. There are 12 kinds of naturally occurring isoflavones in soybean, which can be divided into 3 categories, namely, Daidzin groups, Genistin groups, daidzein glycosides (glycin groups), each type of free type (aglycone), glucoside type, acetyl glucoside type, malonyl glucoside type 4 forms. Isoflavone content in various soybeans is about 1200~4216 & micro;g/g, with isoflavone glucoside and malonyl isoflavone glucoside as the main form, A total of 95% to 98% of total isoflavones; And free isoflavones (aglycones) content is very low.

• Plant source:	Soybean
  EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
  properties	genistein is light yellow crystalline powder; The air is slight and the taste is bitter.
  Use	Genistein has the properties of estrogen and anti-estrogen, has an antioxidant effect, can inhibit the activity of tyrosine protein kinase (PTK), and can inhibit the activity of topological xenoenzyme Ⅱ. It has the effects of inducing programmed cell death, improving anti-cancer efficacy, and inhibiting angiogenesis. It is a potential cancer chemoprevention agent, its anti-cancer effect and mechanism have broad application prospects. Anti-tumor, antifungal, blood-lowering Buddha, estrogen spell activity. for anti-tumor, anti-fungal, lower blood lipid 1, with estrogen and anti-estrogen properties 2, in vivo can inhibit colon cancer, breast cancer, skin cancer, prostate cancer, etc. 3, has inhibitory effect on a variety of tumor cell lines 4, has antioxidant effect 5, can inhibit the activity of tyrosine protein kinase (PTK) 6, can inhibit the activity of topoheterocytase Ⅱ 7, can prevent postmenopausal osteoporosis 8, has the effects of inducing programmed cell death, improving anti-cancer efficacy, inhibiting angiogenesis, etc, it is a potential cancer chemoprevention agent, and its anti-cancer effect and mechanism have a wide range of applications. tyrosine protein kinase (PTK) inhibitors, competitive inhibitors of ATP in other protein kinase reactions, induce programmed cell death, improve anti-cancer efficacy, inhibit angiogenesis, etc.
  Pharmacological effects	Genistein, also known as genistein, is a polyphenolic compound that can be found in plants such as soybeans and red clover. Its molecular structure is similar to 17 β-estradiol. It has antioxidant properties and high affinity for estrogen receptors. It can inhibit the activity of tyrosine protein kinase (PTK) and topoheterooxyase II, it has the effects of inducing programmed cell death, improving anti-cancer efficacy, and inhibiting angiogenesis. It is a type of flavonoids (also called isoflavones). Often found with isoflavones called daidzein, they are all called soy isoflavones. The health benefits of these compounds have been extensively studied and are a potential cancer chemoprevention agent with a significant impact on the prevention of cancer and other diseases. Genistein is the main phytoestrogens currently studied. Plant source: Leguminosae dye wood (gorse). clinical application: it can be used for women's beauty care and prevention of blood diseases and cancer. Genistein has a polyphenol hydroxyl structure. The hydrogen atom on the phenolic hydroxyl group is easy to separate from the oxygen atom under the external action to form hydrogen ions and exert a reducing effect. This is the antioxidant and reducing effect of genistein. Structural basis. Therefore, such substances in food can resist superoxide anion free radicals, block the chain reaction of free radicals, and exert antioxidant effects. Genistein is not a hormone, but because it can bind to estrogen receptors to exert a weak estrogen effect, it is called phytoestrogen. Since the activity of isoflavones is 1/1000 of estradiol, they competitively bind to estrogen receptors with estradiol, showing two-way regulation, and the estrogen effect produced is much lower than the harmful effect of estradiol. It has a protective effect on hormone-related diseases, such as menopausal syndrome, osteoporosis, elevated blood lipids, etc.; for those with high estrogen levels, it exhibits anti-estrogen activity, which can prevent breast cancer and endometritis, and has a two-way regulation of balance function. genistein on trinitrotoluene WR1339 induced hyperlipidemia in rats, has the effect of reducing the serum cholesterol and triglyceride, especially for the latter.

Details

Genistein

Mol Download Chemical properties

CAS:

446-72-0

MF:

C15H10O5

MW:

270.24

EINECS:

207-174-9

MDL No.:

MFCD00016952

Properties

Melting point:

297-298 °C

Boiling point:

333.35°C (rough estimate)

Density 

1.2319 (rough estimate)

refractive index 

1.6000 (estimate)

storage temp. 

-20°C

solubility 

DMSO: soluble

pka

6.51±0.20(Predicted)

form 

powder

color 

off-white

Water Solubility 

insoluble

Merck 

14,4391

BRN 

263823

Stability:

Light Sensitive

InChIKey

TZBJGXHYKVUXJN-UHFFFAOYSA-N

LogP

3.114 (est)

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