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CAS NO.42461-84-7
98%(500-1000)Kilogram98%(100-500)Metric Ton
Flunixin meglumine
CAS: 42461-84-7
Molecular Formula: C21H28F3N3O7
| Name | Flunixin meglumine |
| Synonyms | Flunixin meglumin Flunixin Meglunine Flunixin meglumine Flunixin Solution, 100ppm flunixinn-methylglucanine ino)-3-pyridinecarboxylate(salt) Flunixin Meglumine injectable grade 1-deoxy-1-(methylamino)-d-glucito2-((2-methyl-3-(trifluoromethyl)phenyl)am 1-deoxy-1-(methylamino)-d-glucito-2-((2-methyl-3-(trifluoromethyl)phenyl)amino |
| CAS | 42461-84-7 |
| EINECS | 255-836-0 |
| InChI | InChI=1/C14H11F3N2O2.C7H17NO5/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-7H,1H3,(H,18,19)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1 |
| Molecular Formula | C21H28F3N3O7 |
| Molar Mass | 491.46 |
| Melting Point | 136.6-137.4 °C |
| Boling Point | 378.7°C at 760 mmHg |
| Specific Rotation(α) | -9～-12゜(D/20℃)(c=12,CH3OH) |
| Flash Point | 182.8°C |
| Water Solubility | soluble |
| Solubility | H2O: freely soluble. Soluble in water, ethanol (96%) and methanol. Almost insoluble in ethyl ester and dichloroform. |
| Vapor Presure | 2.08E-06mmHg at 25°C |
| Appearance | white to beige( powder) |
| Color | off-white |
| Storage Condition | room temp |
| MDL | MFCD01725419 |
| Physical and Chemical Properties | White or off-white powder. Soluble in water ethanol (96%) and methanol. Practically insoluble in ethyl ester and dichloroform. |
| Use | Veterinary medicine, can relieve muscle abnormalities caused by inflammation and pain, relieve the horse's internal colic, treatment of foal Diarrhea, trembling, colitis, respiratory and other system diseases |
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 2811 6.1 / PGI |
| WGK Germany | 3 |
| RTECS | LZ4367000 |
| HS Code | 29339900 |
| Reference
Show more |
1. Song Yanbo, Zhao Guishan, Ru Xiaofei, Hou Xiaolin, Mengzhou, Li Xinjie, Meng Qingrong, Wang Xiaodong. Preparation of ... |
| introduction | flunixin meglumine is a veterinary anti-inflammatory analgesic with antipyretic, anti-inflammatory and analgesic effects. alone or in combination with antibiotics can significantly improve clinical symptoms and enhance the activity of antibiotics. Veterinary medicine is often used to relieve the pain and anti-inflammatory caused by visceral colic, muscle and bone disorders of horses; the control of acute inflammation caused by various diseases of cattle, such as hoof lobitis, arthritis, etc., and can also be used for adjuvant treatment of sow mastitis, metritis and breast-free syndrome. |
| preparation | (1) adding 2-chloronicotinic acid and 2-methyl -3-trifluoromethylaniline into sodium hydroxide aqueous solution and stirring, the molar ratio of 2-chloronicotinic acid to 2-methyl -3-trifluoromethylaniline is 3:1; the molar ratio of 2-chloronicotinic acid to sodium hydroxide used for preparing sodium hydroxide aqueous solution is 1:2; add ethylene glycol, chain polyethylene glycol dialkyl ether and catalyst A, the amount of the chain polyethylene glycol dialkyl ether is 3% of the mass of 2-chloronicotinic acid; the catalyst A is p-toluenesulfonic acid and copper oxide, the molar ratio of p-toluenesulfonic acid to copper oxide is 3:1; the temperature is controlled at 45°C, and after 0.6 hours of reaction, the pH of the solution is adjusted, after stirring, it is left to layer, after stirring, filtering, washing the filter cake, (2) reacting flunisin and N-methylglucosamine obtained in step (1) in isopropyl alcohol, the molar ratio of flunisin to N-methylglucosamine is 2:1; the volume ratio of flunisin to isopropyl alcohol is 1:11; adding maltodextrin at the same time; the molar ratio of maltodextrin and 2-methyl-3-trifluoromethylaniline is 1:2.5; heating reflux, filtration, cooling, stirring crystallization, until the system temperature drops below 25 ℃ to continue stirring, crystal suction filtration and isopropyl alcohol washing to obtain flunigine meglumine. |
| use | veterinary anti-inflammatory analgesic, which is used in horses and can relieve inflammation and pain caused by muscle abnormality, relieve visceral colic of horses, and treat diarrhea, tremor, colitis, respiratory diseases, eye surgery, etc. It is used in cattle to treat respiratory diseases and mastitis caused by endotoxin. For dogs, treat arthritis This medicine is used in horses, can relieve inflammation and pain caused by muscle anomalies, relieve horse visceral colic, and treat colt diarrhea, tremor, colitis, respiratory diseases, eye surgery, etc. It is used in cattle to treat respiratory diseases and mastitis caused by endotoxin. Used in dogs to treat arthritis, fever, diarrhea, tremor, eye infection, etc. Used for pigs, treating diarrhea, etc. veterinary drugs can relieve inflammation and pain caused by muscle abnormality, relieve visceral colic of horses, and treat diarrhea, tremor, colitis, respiratory and other system diseases of foals |
| biological activity | Flunixin Meglumin is an effective cyclooxygenase inhibitor, used as an analgesic, with anti-inflammatory and antipyretic activity. |
| Target | Value |
Mol Download Chemical properties
CAS:
42461-84-7
MF:
C21H28F3N3O7
MW:
491.46
EINECS:
255-836-0
MDL No.:
MFCD01725419
Melting point:
136.6-137.4 °C
alpha
-9～-12゜(D/20℃)(c=12,CH3OH)
storage temp.
room temp
solubility
H2O: freely soluble
form
solid
color
off-white
Water Solubility
soluble
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
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