Xi`an Eastling Biotech Co., Ltd.
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CAS NO.38304-91-5
98%(500-1000)Kilogram98%(100-500)Metric Ton
| Molecular Formula | C9H15N5O |
| Molar Mass | 209.25 |
| Density | 1.1651 (rough estimate) |
| Melting Point | 272-274 °C (dec.) (lit.) |
| Boling Point | 348.61°C (rough estimate) |
| Flash Point | 283.364°C |
| Water Solubility | Soluble in water (2.2 mg/ml), 100% ethanol (29 mg/ml), propylene glycol, acetone, DMSO (6.5 mg/ml), and methanol. |
| Solubility | Slightly soluble in ethanol and chloroform, almost insoluble in water |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Crystalline powder |
| Color | White |
| Merck | 14,6203 |
| pKa | 4.61(at 25℃) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Refractive Index | 1.7610 (estimate) |
| MDL | MFCD00063409 |
| Physical and Chemical Properties |
Appearance: White Crystal Melting Point: 258-262 ℃ |
| Use | Antihypertensive drugs for the treatment of refractory, primary, or renal hypertension |
| introduction | minoxidil alias long pressure setting, minoxidin, molecular formula and relative molecular mass C9H15N5O = 209.25, white or white-like crystalline powder, slightly soluble in water or chloroform, slightly soluble in ethanol, slightly soluble in acetone, soluble in glacial acetic acid. It can directly act on the blood vessel wall, expand small arteries, reduce peripheral resistance, reduce blood pressure, and increase heart rate and cardiac output, but its antihypertensive effect is more significant and lasting than hydralazine. |
| pharmacological action | minoxidil directly dilates arterioles, thus lowering blood pressure, but the specific mechanism is unknown. This product does not dilate small veins. The decrease of peripheral vascular resistance causes the increase of reflex heart rate and cardiac output. After lowering blood pressure, renin activity increases, causing water and sodium retention. This product does not interfere with vascular motor reflex, so orthostatic hypotension does not occur. Minoxidil is a commonly used and effective drug for the treatment of alopecia, but its pharmacological effects and target cells are not very clear. Recent studies have shown that minoxidil may promote hair growth through the following ways. |
| A clinically used oral medicine for lowering blood pressure | Minoxidil is a clinically used oral medicine for lowering blood pressure, also known as long-pressure, piperazine Diamine, antihypertensive, Minle Xuedin, belong to potassium channel openers, can directly relax vascular smooth muscle, have a strong arteriolar dilation effect, reduce peripheral resistance, dilate blood vessels, and drop blood pressure, it has no effect on the volume of blood vessels, so it can promote venous return. At the same time, due to reflex regulation and positive frequency, cardiac output and heart rate can be increased, but it does not cause orthostatic hypotension. It is clinically used for the treatment of refractory hypertension and renal hypertension. It can also be used for severe hypertension with poor effect on other antihypertensive drugs, but it needs to be combined with diuretic drugs to avoid water and sodium retention, and combined with β-receptor blocking drugs can increase its efficacy and reduce adverse reactions. Long-term use of minoxidil may have a side effect, that is, body hair may increase slightly with the continuous use of the drug, such as arm hair. But generally within the acceptable range. The main adverse reactions of oral administration are: weight gain and lower limb edema caused by water and sodium retention, palpitations and arrhythmia caused by reflex sympathetic nerve excitement, hirsutism, etc. The adverse reactions of topical preparations are mainly: skin irritation, erythema, itching and other dermatitis reactions at the medication site. Although the amount of absorption in topical preparations is very small, it cannot be ruled out that it will affect the condition of patients with a history of heart disease. When suffering from cerebrovascular disease, heart failure caused by non-hypertension, coronary heart disease, angina pectoris, myocardial infarction, pericardial effusion, renal dysfunction and other diseases, it must be used with caution. It is allergic to minoxidil and pheochromocytoma Patients should be disabled. |
| use | antihypertensive drugs for refractory, primary or renal hypertension. Used to prevent fat hair loss and animal husbandry. Antihypertensive drugs for the treatment of refractory, primary or renal hypertension |
| Production method | 4-chloro-2, 6-diaminopyrimidine (see 08910) is obtained from methyl cyanoacetate by cyclization and chlorination, and then oxidized with perbenzoic acid to obtain 6-amino -1, 2-dihydro-1-hydroxy-2-imino-4-chloropyrimidine (C4H5CIN4O), finally, it is condensed with hexahydropyridine to obtain Minrodine. |
CAS:
38304-91-5
MF:
C9H15N5O
MW:
209.25
EINECS:
253-874-2
MDL No.:
MFCD00063409
Melting point:
272-274 °C (dec.) (lit.)
Boiling point:
348.61°C (rough estimate)
Density
1.1651 (rough estimate)
refractive index
1.7610 (estimate)
storage temp.
2-8°C
solubility
Slightly soluble in water, soluble in methanol and in propylene glycol.
pka
4.61(at 25℃)
color
White
Water Solubility
Soluble in water (2.2 mg/ml), 100% ethanol (29 mg/ml), propylene glycol, acetone, DMSO (6.5 mg/ml), and methanol.
Merck
14,6203
BCS Class
3
Stability:
Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey
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Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.