Xi`an Eastling Biotech Co., Ltd.
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CAS NO.33818-15-4
98%(500-1000)Kilogram98%(100-500)Metric Ton
CAS: 33818-15-4
Molecular Formula: C14H27N4NaO11P2
| Name | cytidine 5'-diphosphocholine sodium salt dihydrate |
| Synonyms | citicoline sodium CITICOLINE SODIUM SALT CYTIDINE-5'-DIPHOSPHOCHOLINE, NA CYTIDINE-5'-DIPHOSPHOCHOLINE, SODIUM CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT CYTIDINE-5'-DIPHOSPHOCHOLINE MONOSODIUM SALT CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT DIHYDRATE cytidine 5'-diphosphocholine sodium salt dihydrate sodium 5'-O-[({[2-(trimethylammonio)ethoxy]phosphinato}oxy)phosphinato]cytidine P'-[2-(TRIMETHYLAMMONIO)ETHYL]ESTER CYTIDINE 5'-(TRIHYDROGEN DIPHOSPHATE) INNER SALT MONOSODIUM cytidine 5'-(trihydrogen diphosphate) p'-[2-(trimethylammonio)ethyl] ester inner salt monosodium salt cytidine 5'-(trihydrogen diphosphate) p'-(2-(trimethylammonio)ethyl) ester inner salt monosodium salt |
| CAS | 33818-15-4 |
| EINECS | 251-689-1 |
| InChI | InChI=1/C14H26N4O11P2.Na/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21;/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25);/q;+1/p-1/t9-,11-,12-,13-;/m1./s1 |
| InChIKey | YWAFNFGRBBBSPD-OCMLZEEQSA-M |
| Molecular Formula | C14H27N4NaO11P2 |
| Molar Mass | 512.32 |
| Melting Point | 259-268°C (dec.) |
| Specific Rotation(α) | D20 +12.5° (c = 1.0 in H2O) |
| Water Solubility | Soluble in water (100 mg/ml). |
| Solubility | H2O: 100mg/mL |
| Appearance | solid |
| Color | white |
| Maximum wavelength(λmax) | ['280nm(HCl aq.)(lit.)'] |
| Merck | 13,2343 |
| BRN | 4110040 |
| Storage Condition | -20°C |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD00150508 |
| Use | Central nervous system medications |
| In vitro study | Citicoline is a complex organic molecule composed of ribose, pyrophosphate, cytosine and choline, the main component of phospholipids in cell membranes. Citicoline is water soluble and its oral bioavailability is greater than 90%. Citicoline has no mitogenic and chemotactic effects on hCMEC/D3. However, it significantly enhanced wound healing, spheroid sprouting, and strongly induced the formation of endothelial tubular structures in the basement membrane matrix. Citicoline was able to induce the expression of phosphorylated ERK1/2. It protects hCMEC/D3 from cell damage/apoptosis. Citicoline induces angiogenesis and improves the survival of human brain microvascular endothelial cells through p-ERK1/2 and IRS-1-related pathways. |
| In vivo study | In the transient ischemia model of reperfusion in rats, Citicoline can increase the nerve cell membrane phospholipids, and reduce the accumulation of free fatty acids, and reverse the neurological deficit. The compound can be rapidly metabolized and the metabolites can participate in various biosynthetic pathways and finally be excreted in the form of carbon dioxide. In rodents and dogs, citicoline has no acute and chronic toxic effects. Citicoline may protect ischemic neurons, it has the effect of protecting blood vessels and promoting angiogenesis. |
Mol Download Chemical properties
CAS:
33818-15-4
MF:
C14H26N4O11P2.Na
MW:
511.31
EINECS:
251-689-1
MDL No.:
MFCD00037486
Melting point:
259-268°C (dec.)
alpha
D20 +12.5° (c = 1.0 in H2O)
storage temp.
-20°C
solubility
H2O: 100mg/mL
form
solid
color
white
Water Solubility
Soluble in water (100 mg/ml).
λmax
280nm(HCl aq.)(lit.)
Merck
13,2343
BRN
4110040
InChIKey
YWAFNFGRBBBSPD-OCMLZEEQSA-M
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.