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CAS NO.304-55-2
98%(500-1000)Kilogram98%(100-500)Metric Ton
| Molecular Formula | C4H6O4S2 |
| Molar Mass | 182.22 |
| Density | 1.439 (estimate) |
| Melting Point | 196-198°C (dec.)(lit.) |
| Boling Point | 285.62°C (rough estimate) |
| Flash Point | 115.622°C |
| Water Solubility | Soluble in water, and ethanol (25 mg/ml, results in colorless to light yellow, clear). |
| Solubility | Soluble in water, and ethanol (25 mg/ml, Colorless to Light Yellow, Clear). |
| Vapor Presure | 0.002mmHg at 25°C |
| Appearance | White crystal |
| Color | White to off-white |
| Merck | 14,8865 |
| BRN | 1725150 |
| pKa | pK1:2.71;pK2:3.48;pK3:8.89(SH);pK4:10.79(SH) (25°C) |
| Storage Condition | -20°C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.5220 (estimate) |
| MDL | MFCD00064799 |
| Physical and Chemical Properties | Properties: white crystalline powder, with the special odor of sulfhydryl compounds. solubility insoluble in water, soluble in alkaline solution, slightly soluble in methanol. |
| Use | Used as a heavy metal antidote, health care drugs |
| In vivo study | Succimer is a widely used chelating agent for the treatment of Pb poisoning. Red blood cells (RBCs) from lead exposed animals treated with NAC or Succimer are shown to have significantly higher glutathione (GSH) levels and diminished malondialdehyde (MDA) levels when compare to the lead group. Succimer administration also results in decreased glucose 6-phosphate dehydrogenase (G6PD) activity in RBCs from lead exposed animals. Succimer treatment produces a significant reduction in blood lead levels for both lead exposure conditions: the High Pb-succ group has blood lead levels that are 27% of the blood lead levels of the High Pb group at the end of treatment. Succimer is effective in substantially reducing brain lead, as brain lead levels in the High Pb-succ group are 37% of levels in the High Pb group. |
This product contains dimercaptosuccinic acid (C4H604S2) should be the label amount of 90.0% ~ 110.0%.
identification
take an appropriate amount of the content of this product (about 200mg equivalent to Dimercaptosuccinic acid), and show the same reaction according to the identification (1) and (2) tests under the item of dimercaptosuccinic acid.
examination
Content determination
The contents under the item of loading amount difference were mixed uniformly, and an appropriate amount (corresponding to about 50mg of dimercaptosuccinic acid) was accurately weighed and measured according to the method under the item of dimercaptosuccinic acid. Each 1 ml of silver nitrate titration solution (0.1 mol/L) corresponds to 4.556mg of C4H504S2.
category
Same as dimercaptosuccinic acid.
specification
0.25g
storage
shade, seal, and store in a cool and dry place.
| introduction | 2, 3-dimercaptosuccinic acid (English abbreviation: DMSA), alias 2, 3-dimercaptosuccinic acid, is an organic sulfur compound, white crystalline powder at room temperature. Because the molecule contains two sulfhydryl groups, it has the unique odor of sulfhydryl compounds. Both dimercaptosuccinic acid and its sodium salt can be used as antidotes to treat heavy metal poisoning by oral or injection. There are two diastereomers of dimercaptosuccinic acid, one is a racemate and the other is a racemate. The racemate can be used as a chelating agent, and its sodium salt is commonly used. |
| biological activity | Succimer (Dimercaptosuccinic acid) is a chelating agent widely used to study lead poisoning. |
| use | this product is an intermediate of antidote sodium dimercaptosuccinate. Used as a heavy metal antidote and health medicine A selective masking agent for cadmium, used for EDTA titration of zinc |
| Production method | is obtained by elimination, addition and hydrolysis of dibromosuccinic acid. |
CAS:
304-55-2
MF:
C4H6O4S2
MW:
182.22
EINECS:
206-155-2
MDL No.:
MFCD00064799
Melting point:
196-198 °C (dec.)(lit.)
Boiling point:
285.62°C (rough estimate)
Density
1.439 (estimate)
refractive index
1.5220 (estimate)
storage temp.
-20°C
solubility
DMSO (Sparingly), Methanol (Slightly, Heated)
form
Powder
pka
pK1:2.71;pK2:3.48;pK3:8.89(SH);pK4:10.79(SH) (25°C)
color
White to off-white
Water Solubility
Soluble in water, and ethanol (25 mg/ml, results in colorless to light yellow, clear).
Merck
14,8865
BRN
1725150
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
ACTRVOBWPAIOHC-XIXRPRMCSA-N
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.