Xi`an Eastling Biotech Co., Ltd.
Diamond Supplier
- Diamond
Supplier - 1st
years
Diamond Supplier
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Lab/Research institutions
Tel: +86-156-91766041
Mobile:
Tel: +86-156-91766041
Fax:
URL: http://www.eastlingbiotech.com/
Province/state: Shaanxi
City: Xi'an city
Street: No. 201, Unit 4, Building 9, Hongqi Community, Tanjia Street, Weiyang District, Xi 'an, Shaanxi
MaxCard:
Contact Suppliers
CAS NO.27200-12-0
98%(1-25)Kilogram98%(26-500)Kilogram98%(501-1000)Kilogram
Dihydromyricetin
CAS: 27200-12-0
Molecular Formula: C15H12O8
| Name | Dihydromyricetin |
| Synonyms | Ampelopsin Dihydromyricetin (+)-Dihydromyricetin Two hydrogenMyricetin DihydroMyricetin, froM Myrica rubra 3,3',4',5,5',7-hexahydroxy-flavanon Dihydromyricetin(+)-Dihydromyricetin 3,3',4',5,5',7-hexahydroxy-2,3-dihydroflavanonol (2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one Ampelopsin(2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one 2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydro-4H-chromen-4-one |
| CAS | 27200-12-0 |
| EINECS | 200-001-8 |
| InChI | InChI=1/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1 |
| InChIKey | KJXSIXMJHKAJOD-LSDHHAIUSA-N |
| Molecular Formula | C15H12O8 |
| Molar Mass | 320.25 |
| Density | 1.808±0.06 g/cm3(Predicted) |
| Melting Point | 239-241 °C |
| Boling Point | 780.7±60.0 °C(Predicted) |
| Flash Point | 296.7°C |
| Solubility | Soluble in hot water, hot ethanol and acetone, soluble in ethanol, methanol, very slightly soluble in ethyl acetate, insoluble in chloroform, petroleum ether. |
| Vapor Presure | 1.16E-25mmHg at 25°C |
| Appearance | White or white-like powder |
| Color | white to beige |
| pKa | 7.38±0.60(Predicted) |
| Storage Condition | -20°C |
| Stability | Hygroscopic |
| Refractive Index | 1.798 |
| MDL | MFCD00189451 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the stems and leaves of Ampelopsis grossedentata. |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29329990 |
| rattan tea extract | dihydromyricetin (dihydromyricetin,DMY) is a wild woody vine (rattan tea) extract of the genus Vitis, also known as dihydrobayberry bark, dihydromyricetin, snake grape, etc. rattan tea is also known as "berry tea", Shentang berry, Maoyan enzyme tea, longevity vine, etc. The folk have the habit of drinking berry tea since ancient times, which can be traced back to the ancient Shennong tasting Baicao period, which has a history of more than 6000 years. The earliest "Book of Songs Collection" in China is called ancient tea gouteng. The taste is bitter first and then sweet, and the return is strong. Dihydromyricetin is an extract of the grape plant Ampelopsis. It is the main active ingredient in Ampelopsis. Flavonoids, such substances have a variety of unique effects such as scavenging free radicals, anti-oxidation, anti-thrombosis, anti-tumor, anti-inflammatory, etc.; and dihydromyricetin is a relatively special kind of flavonoid compound, it has special effects in relieving alcohol poisoning, preventing alcoholic liver and fatty liver, inhibiting liver cell deterioration, reducing the incidence of liver cancer, anti-hypertension, inhibiting platelet aggregation in vitro and thrombosis in vivo, reducing blood lipid and blood sugar levels, improving SOD activity and protecting liver and liver. |
| Biological activity | Dihydromyricetin is an antioxidant and a competitive GABAA antagonist. Dihydromyricetin competitively inhibits benzodiazepine sites, induces autophagy and shows antiproliferative effects. |
| pharmacological action | myricetin is one of the main active ingredients of rattan tea. it has a variety of biological functions and has a variety of unique effects such as scavenging free radicals, anti-oxidation, anti-hypertension, anti-thrombosis, anti-tumor, anti-inflammatory, etc. Dihydromyricetin, as a special flavonoid compound, in addition to the general characteristics of flavonoids, also has the effects of relieving alcoholism, preventing alcoholic liver, fatty liver, inhibiting liver cell deterioration, and reducing the incidence of liver cancer. It is a good product to protect the liver and protect the liver, relieve alcohol and sober up. Antibacterial effect: Pharmacological experiments show that dihydromyricetin has antibacterial effects on Bacillus subtilis, Staphylococcus aureus, Salmonella, Escherichia coli, Aerogenes, Saccharomyces cerevisiae, Penicillium, Aspergillus niger, Aspergillus flavus, Mucor and Rhizopus, especially on Gram-positive, Gram-negative cocci or bacilli. Regulating effect on blood sugar and blood lipids: The experiment of gavage in mice showed that dihydromyricetin can significantly inhibit the increase in blood sugar in mice induced by alloxan, epinephrine, and streptozotocin, and increase serum insulin. Levels, lymphocyte infiltration in pancreatic tissue is significantly reduced, inflammation is significantly reduced, and the number of islets is significantly increased. Dihydromyricetin can reduce the content of serum triglyceride (TG) in streptozotocin-induced hyperglycemia rats, but has no obvious effect on the content of serum total cholesterol (TC) and high density lipoprotein cholesterol (HDL2C). Liver protection: Dihydromyricetin has a significant protective effect on toxic damage of carbon tetrachloride in rat hepatocytes cultured in vitro, and liver injury induced by D2 galactosamine and lipopolysaccharide in mice. Dihydromyricetin can protect the liver, accelerate the rapid decomposition of the ethanol metabolite acetaldehyde, become a non-toxic substance, and reduce its damage to liver cells. In addition, dihydromyricetin can improve the increase of serum lactate dehydrogenase activity caused by liver cell damage, inhibit the formation of hepatic M cell collagen fibers, thereby protecting the liver and greatly reducing the damage of ethanol to the liver. The normal state of the liver is quickly restored. Microherb tests have proved that dihydromyricetin can protect the liver, accelerate the rapid decomposition of the ethanol metabolite acetaldehyde, turn into a non-toxic substance, and reduce the damage to liver cells. Dihydromyricetin takes effect quickly and has a long-lasting effect. It is a good product for protecting the liver and relieving alcohol and sobering up. Antioxidant effect: Dihydromyricetin with 98% purity can obviously inhibit the production of malondialdehyde (MDA) in homogenate of rat myocardium, liver and brain tissue, and inhibit the production of MDA with the increase of dihydromyricetin concentration. The scavenging rate of diphenyltrinitrophenylhydrazine (DPPH) radical in the test system with 99% content of dihydromyricetin. Dihydromyricetin can obviously inhibit the formation of MDA in oil, and its antioxidant effect is enhanced with the increase of dihydromyricetin purity (60% ~ 90%). It has strong antioxidant effect on animal oil and vegetable oil. Anti-tumor effect: In recent years, anti-tumor pharmacodynamics studies have found that one of its active ingredients, the small molecule compound of snake grape-grape, has a relatively strong anti-cancer effect. In vitro anti-tumor effect studies have found that the compound can improve the effect of tumor treatment and improve the patient's life symptoms by inhibiting tumor vascular growth and regulating and enhancing cellular immune function. It has been used in tumor model tests such as leukemia and nasopharyngeal carcinoma. It has shown obvious anti-tumor effect. |
Mol Download Chemical properties
CAS:
27200-12-0
MF:
C15H12O8
MW:
320.25
EINECS:
200-001-8
MDL No.:
MFCD00189451
storage temp.
-20°C
solubility
DMSO: ≥5mg/mL (warmed)
Density
1.808±0.06 g/cm3(Predicted)
form
powder
Boiling point:
780.7±60.0 °C(Predicted)
Melting point:
239-241 °C
pka
7.38±0.60(Predicted)
color
white to beige
Stability:
Hygroscopic
InChI
InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1
InChIKey
KJXSIXMJHKAJOD-LSDHHAIUSA-N
SMILES
[C@H]1(C2=CC(O)=C(O)C(O)=C2)OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O
LogP
1.230 (est)
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.