Xi`an Eastling Biotech Co., Ltd.
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Province/state: Shaanxi
City: Xi'an city
Street: No. 201, Unit 4, Building 9, Hongqi Community, Tanjia Street, Weiyang District, Xi 'an, Shaanxi
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CAS NO.27113-22-0
98%(500-1000)Kilogram98%(100-500)Metric Ton
6-paradol
CAS: 27113-22-0
Molecular Formula: C17H26O3
| Molecular Formula | C17H26O3 |
| Molar Mass | 278.39 |
| Density | 1.0690 g/cm3 |
| Boling Point | 406.4±30.0 °C(Predicted) |
| JECFA Number | 2021 |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Brown |
| pKa | 10.02±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.5232 (589.3 nm 20℃ |
| In vitro study | Paradol ([6]-paradol) induces apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. Paradol induces apoptosis through a caspase-3-dependent mechanism. |
| In vivo study | Administration of Paradol (6-paradol) (10 mg/kg) clearly reduces the number of Iba1-positive cells 1 and 3 days after the challenge. Moreover, Paradol dramatically reduces the number of Iba1-postive cells in periischemic regions even after 3 days following M/R challenge. Paradol (6-paradol) exhibits the strongest anti-inflammatory effect of several paradol compounds in lipopolysaccharide-stimulated BV2 microglia derived from a mouse brain, including 2-, 4-, 6-, 8-, and 10-paradol. Furthermore, Paradol shows the strongest pungency of all of the known paradol analogues. Paradol also shows the highest contact time at the antiobesity site of action on the basis of the results shown for the absorption of the metabolites in this study. |
| FEMA | 4665 | 1-(4-HYDROXY-3-METHOXYPHENYL)DECAN-3-ONE |
| Use | 5-deoxy-6-gingerol is an intermediate in organic synthesis and a pharmaceutical intermediate, mainly used in laboratory research and development process and chemical and pharmaceutical synthesis process. |
| biological activity | paradigm is a pungent phenolics found in Zingiberaceae. In mouse skin carcinogenesis, paraol binds to the active site of cyclooxygenase (COX-2), effectively inhibiting tumor development. |
Mol Download Chemical properties
CAS:
27113-22-0
MF:
C17H26O3
MW:
278.39
EINECS:
248-228-1
MDL No.:
MFCD01736103
Boiling point:
406.4±30.0 °C(Predicted)
Density
1.0690 g/cm3
FEMA
4665 | 1-(4-HYDROXY-3-METHOXYPHENYL)DECAN-3-ONE
refractive index
1.5232 (589.3 nm 20℃)
storage temp.
Sealed in dry,Room Temperature
solubility
Chloroform (Slightly), Methanol (Slightly)
pka
10.02±0.20(Predicted)
form
Solid
color
White to Brown
Odor
spicy herbal
Odor Type
spicy
JECFA Number
2021
LogP
3.83
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.