Keywords

• Clobetasol propionate
• 25122-46-7
• clobetasol propionate

Quick Details

• ProName: Factory high quality Clobetasol propio...
• CasNo: 25122-46-7
• Molecular Formula: C25H32ClFO5
• Appearance: white powder
• Application: Dietary supplements;Food;Additives;Pha...
• DeliveryTime: 7
• PackAge: 1kg/bag,5kg/bag,25kg/drum
• Port: any port in china
• ProductionCapacity: 1 Metric Ton/Day
• Purity: purity 98%-101%
• Storage: 20°
• Transportation: 20
• LimitNum: 1 Gram
• Related Substances: 1
• Residue on Ignition: 1
• Heavy Metal: 1
• Valid Period: 1

Superiority

clobetasol propionate

CAS: 25122-46-7

Molecular Formula: C25H32ClFO5

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25122-46-7 - Names and Identifiers

25122-46-7 - Physico-chemical Properties

This product contains clobetasol propionate (C25H32CIFO5) should be 90.0% ~ 110.0% of the label amount.

trait

This product is white cream.

identification

In the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the control solution.

examination

should comply with the relevant provisions under Cream (General rule 0109).

Content determination

• measured by high performance liquid chromatography (General 0512).
• chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Methanol-water (65:35) as mobile phase; The detection wavelength was 240nm. The number of theoretical plates shall not be less than 2000 based on clobetasol propionate peak. The separation degree between the peak of Clobetasol propionate and the peak of internal standard substance shall meet the requirements. Preparation of internal standard solution fluorine acetate was easily taken, dissolved in methanol and diluted to prepare a solution containing about 0.15mg per 1ml.
• determination: take an appropriate amount of this product (about 1 mg equivalent to clobetasol propionate), weigh it accurately, put it in a 50ml measuring flask, add 5ml of internal standard solution accurately, and add about 30ml of methanol, heat in a 60°C water bath for 5 minutes, carefully shake to dissolve clobetasol propionate, let it cool, dilute with methanol to the scale, shake well, cool in an ice bath for more than 2 hours, take it out and quickly filter, the filtrate was taken to room temperature as a test solution, and 20u1 was injected into the liquid chromatograph to record the chromatogram, add methanol to dissolve and dilute quantitatively to make a solution containing about 0.2mg per 1ml. Take 5ml of the solution and 5ml of the internal standard solution precisely, put them in a 50ml measuring flask, and dilute to the mark with methanol, shake well, take a liquid chromatograph and record the chromatogram. According to the internal standard method to calculate the peak area, that is.

• overview	clobetasol propionate is a dermatological drug. External use is suitable for chronic eczema, neurodermatitis, psoriasis, palmoplantar pustulosis, lichen planus, discoid lupus erythematosus and other glucocorticoids for external use to treat effective pruritic and non-infectious inflammatory skin diseases.
  pharmacology and toxicology	this product has rapid action and is one of the highly effective topical corticosteroids currently used clinically. It has a strong capillary contraction effect, and its anti-inflammatory effect is 112.5 times that of hydrocortisone, 2.3 times that of betamethasone sodium phosphate, and 18.7 times that of fluocinolone. The systemic adverse reactions are 3 times that of fluocinolone, anhydrous sodium retention, and it has a certain effect of promoting sodium and potassium excretion.
  biological activity	Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin diseases.
  Target	Value
  use	clobetasol propionate is a synthetic and efficient topical glucocorticoid drug. It has strong anti-inflammatory, anti-pruritic and capillary contraction effects It is a drug of adrenocorticotropic hormone and adrenocorticotropic hormone. Clobetasol propionate is a synthetic and efficient topical glucocorticoid drug. It has strong anti-inflammatory, anti-pruritic and capillary contraction effects
  category	toxic substances
  toxicity classification	poisoning
  acute toxicity	oral-rat LD50: >3000 mg/kg; Oral-mouse LD50; >3000 mg/kg
  flammability hazard characteristics	combustible; combustion produces toxic chloride and fluoride smoke
  storage and transportation characteristics	warehouse ventilation and low temperature drying
  fire extinguishing agent	dry powder, foam, sand, carbon dioxide, mist water

Details

Clobetasol propionate

CAS:

25122-46-7

MF:

C25H32ClFO5

MW:

466.97

EINECS:

246-634-3

MDL No.:

MFCD00058499

Properties

Melting point:

195.5-1970C

alpha 

D +103.8° (c = 1.04 in dioxane)

Boiling point:

569.0±50.0 °C(Predicted)

Density 

1.1653 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

Practically insoluble in water, freely soluble in acetone, sparingly soluble in ethanol (96 per cent).

pka

12.88±0.70(Predicted)

InChIKey

CBGUOGMQLZIXBE-XGQKBEPLSA-N

SMILES

O([C@@]1([C@H](C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)C(=O)CCl)C(=O)CC |&1:1,2,4,6,16,18,20,23,r|

Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.

Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.

We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.

We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.