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CAS NO.157115-85-0
99%(1-25)Kilogram99%(26-100)Metric Ton99%(101-500)Kilogram
CAS: 157115-85-0
Molecular Formula: C17H22N2O4
| Name | ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate |
| Synonyms | Noopept GVS 111 SGS 111 GVS-111 noopept powder Nootropic GVS-111 ethyl phenylacetyl-Pro-Gly Ethyl 1-(phenylacetyl)-L-prolylglycinate ethyl 1-(phenylacetyl)-L-prolylglycinate N-(1-(Phenylacetyl)-L-prolyl)glycineethylester N-(1-(Phenylacetyl)-L-prolyl)glycine ethyl ester Glycine, 1-(phenylacetyl)-L-prolyl-, ethyl ester Glycine, N-(1-(phenylacetyl)-L-prolyl)-, ethyl ester (S)-ethyl 2-(1-(2-phenylacetyl)pyrrolidine-2-carboxaMido)acetate ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate |
| CAS | 157115-85-0 |
| EINECS | 1592732-453-0 |
| InChI | InChI=1/C17H22N2O4/c1-2-23-16(21)12-18-17(22)14-9-6-10-19(14)15(20)11-13-7-4-3-5-8-13/h3-5,7-8,14H,2,6,9-12H2,1H3,(H,18,22)/t14-/m0/s1 |
| Molecular Formula | C17H22N2O4 |
| Molar Mass | 318.37 |
| Density | 1.202±0.06 g/cm3(Predicted) |
| Melting Point | 94.0 to 98.0 °C |
| Boling Point | 547.3±50.0 °C(Predicted) |
| Flash Point | 284.8°C |
| Solubility | Soluble in DMSO (up to 25 mg/ml) |
| Vapor Presure | 4.93E-12mmHg at 25°C |
| Appearance | powder |
| Color | white to beige |
| pKa | 13.41±0.20(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| Refractive Index | 1.548 |
| In vitro study | Nooglutil exhibits pharmacologically significant competition with a selective agonist of AMPA receptors ([G-3H]Ro 48-8587) for the receptor binding sites (with IC50 = 6.4 +/- 0.2 microM), while the competition of noopept for these receptor binding sites was lower by an order of magnitude (IC50 = 80 +/- 5.6 microM) [1]. GVS-111 significantly increased neuronal survival after H(2)O(2)-treatment displaying a dose-dependent neuroprotective activity from 10 nM to 100 microM, and an IC(50) value of 1.21+/-0.07 microM. GVS-111 inhibited the accumulation of intracellular free radicals and lipid peroxidation damage in neurons treated with H(2)O(2) or FeSO(4), suggesting an antioxidant mechanism of action [2]. |
| In vivo study | N-Phenylacetyl-L-prolylglycine ethyl ester (GVS-111) administered intravenously at a dose of 0.5 mg/kg/day, for the first time 1 h after ischaemic lesion and then for 9 post-operative days, with the last administration 15 min before testing, attenuated the deficit [3]. GVS-111 itself was not found in rat brain 1 h after 5 mg/kg i.p. administration up to limit of detection (LOD) under high performance liquid chromatography (HPLC) conditions [4]. The most pronounced antiinflammatory effect of dipeptide was observed on the model of adjuvant arthritis in rats, where the drug administered over 25 days in a daily dose of 0.5 mg/kg (i.m.) or 5 mg/kg (p.o.) significantly reduced the chronic immune inflammation (on the 12th day, by 94.0 and 74.1%, respectively) [5]. |
Mol Download Chemical properties
CAS:
157115-85-0
MF:
C17H22N2O4
MW:
318.37
EINECS:
1592732-453-0
MDL No.:
MFCD00941121
Melting point:
94.0 to 98.0 °C
Boiling point:
547.3±50.0 °C(Predicted)
Density
1.202±0.06 g/cm3(Predicted)
storage temp.
-20°C
solubility
Soluble in DMSO (up to 25 mg/ml)
pka
13.41±0.20(Predicted)
form
powder
color
white to beige
optical activity
[α]/D -115 to -125°, c = 0.5 in chloroform-d
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChI
InChI=1S/C17H22N2O4/c1-2-23-16(21)12-18-17(22)14-9-6-10-19(14)15(20)11-13-7-4-3-5-8-13/h3-5,7-8,14H,2,6,9-12H2,1H3,(H,18,22)/t14-/m0/s1
InChIKey
PJNSMUBMSNAEEN-AWEZNQCLSA-N
SMILES
C(OCC)(=O)CNC(=O)[C@@H]1CCCN1C(CC1=CC=CC=C1)=O
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.