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CAS NO.141433-60-5
98%(1-25)Kilogram98%(26-500)Kilogram98%(501-1000)Kilogram
BERBERINE CHLORIDE
CAS: 141433-60-5
Molecular Formula: C20H18NO4.Cl.xH2O
| Molecular Formula | C20H18NO4.Cl.xH2O |
| Molar Mass | 371.81(as Anhydrous) |
| Melting Point | 204-206 °C (dec.) |
| Water Solubility | Soluble in water. |
| Appearance | Yellow powder |
| Storage Condition | Room Temprature |
| MDL | MFCD00011939 |
| Use | Use 1. Plant antibiotics for the treatment of intestinal infections. 2. For fluorescent staining of heparin sodium in mast cells. 3. An alkaloid with weak antibiotic properties, a substrate for Bacterial multi-drug resistant efflux pumps. The antimicrobial activity of berberine can be enhanced by the MDR inhibitor 5 '-methoxyhydnocarpin(5'-MHC). Berberine regulates the expression of Pgp gene in hepatocellular carcinoma cells. |
Berberine chloride is a soluble yellow crystalline solid, commonly used as an antibacterial, antiviral, and anticancer medication. It exhibits various pharmacological activities, including anti-inflammatory, antioxidant, and blood sugar-regulating effects.
Berberine chloride is a clear solution with a pH of around 4-7. It has high solubility in water but lower solubility in organic solvents. Berberine chloride can be administered orally, by injection, or topically, but may cause gastrointestinal discomfort at high doses.
Properties:
- Berberine chloride is a yellow crystalline solid that is soluble in water, forming a clear solution.
- It possesses various pharmacological activities, including antibacterial, antiviral, anti-inflammatory, antioxidant, and blood sugar-regulating effects.
Uses:
- Berberine chloride is commonly used as a medication ingredient with antimicrobial and antiviral properties.
- It is widely utilized in traditional herbal medicine to treat various infections, inflammation, and metabolic disorders.
- Some studies also suggest that berberine chloride may have inhibitory effects on certain tumor cells.
Preparation:
- Berberine chloride is primarily extracted from plants of the Berberidaceae family, such as goldenseal and Chinese goldthread.
- It is typically prepared by solvent extraction and crystallization purification methods.
Safety:
- Berberine chloride is generally considered safe in moderate amounts and is a commonly used herbal ingredient.
- However, high doses may result in adverse reactions such as gastrointestinal discomfort.
- Pregnant and lactating women should avoid berberine chloride as its safety in these populations is uncertain. It is recommended to consult a healthcare provider or pharmacist before use.
berberine hydrochloride (BC) was extracted and purified from Coptis chinensis Franch. The interaction between BC and bovine serum albumin (BSA) was studied by UV spectrum and fluorescence spectrum (FS), the phenomenon that the fluorescence emission spectrum of BSA is split by BC is explained, and the two heavy peaks belong to tryptophan and tyrosine residues respectively. The results show that the static quenching and non radiation energy transfer are the two major reasons for the fluorescence quenching of BSA by BC, the apparent binding constants KA of BC and BSA were 8.66 × 1 0 4 L/mol( 3 0 ℃) and 8.72 × 1 0 4 L/mol( 3 7 ℃ ) , the number of binding sites of BC on the BSA molecule is (3 .1±0 .2) No. The distance between the fluorescent amino acid residues in the BC and BSA molecules was 3 .75 nm (30 C) and 3 .62 nm (37 ℃ ) , indicating that part of the BC fragment can be inserted into the BSA molecule. The thermodynamic function calculation results show that the interaction process is a spontaneous supramolecular interaction process with an increase in entropy and a decrease in Gibbs free energy, and it is concluded that the hydrophobic interaction between BC and BSA is the main one.
Mol Download Chemical properties
CAS:
141433-60-5
MF:
C20H20ClNO5
MW:
389.83
EINECS:
211-195-9
MDL No.:
MFCD00011939
Melting point:
204-206 °C (dec.)
storage temp.
Sealed in dry,Room Temperature
solubility
DMSO (Slightly), Methanol (Slightly)
Colour Index
75160
form
Solid
color
Pale Yellow to Yellow
Water Solubility
Soluble in water.
Sensitive
Light Sensitive
Merck
14,1154
BRN
3836585
Stability:
Hygroscopic
InChIKey
VKJGBAJNNALVAV-UHFFFAOYSA-M
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.