Xi`an Eastling Biotech Co., Ltd.
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Province/state: Shaanxi
City: Xi'an city
Street: No. 201, Unit 4, Building 9, Hongqi Community, Tanjia Street, Weiyang District, Xi 'an, Shaanxi
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CAS NO.13739-02-1
98%(1-25)Kilogram98%(26-500)Kilogram98%(501-1000)Kilogram
| Molecular Formula | C19H12O8 |
| Molar Mass | 368.29 |
| Density | 1.491±0.06 g/cm3(Predicted) |
| Melting Point | 217-2180C |
| Boling Point | 631.5±55.0 °C(Predicted) |
| Flash Point | 231.8°C |
| Water Solubility | 240μg/L at 25℃ |
| Solubility | Easily soluble in dimethyl sulfoxide and dimethyl acetamide; hardly soluble in water, methanol and chloroform. |
| Vapor Presure | 8.17E-17mmHg at 25°C |
| Appearance | Orange-yellow long needle crystal (orange crystal in acetone, yellow crystal in methanol) |
| Color | Light Yellow to Yellow |
| Merck | 14,2960 |
| pKa | 3.01±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.634 |
| MDL | MFCD00468030 |
| Use | This product is an important inhibitor of osteoarthritis IL-1. Used for osteoarthritis |
| Immunosuppressive drugs | Diacetate, also known as diacetyl dihydroanthracene carboxylic acid, 1, 8-diacetyl -3-carboxyl anthraquinone, daceruin, and ambidine, is a new interleukin (IL)-1 inhibitor, the chemical name is diacetyl rheoic acid, which is an anthraquinone compound, this product can induce cartilage formation, has analgesic, anti-inflammatory and antipyretic effects, can also significantly improve the joint function of patients with osteoarthritis, delay the course of disease, relieve pain, improve the quality of life of patients, and has good safety. It is mainly used in the treatment of osteoarthritis (OA) and plays an antibacterial role. Solubility: easily soluble in dimethyl sulfoxide and dimethyl acetamide; hardly soluble in water, methanol and chloroform. diacenine and its active metabolite rhein reduce the production and activity of IL-1β by inhibiting IL-1 converting enzyme. The mechanism of action includes: 1, inhibiting the synthesis of IL-1 in synovial tissue. 2, inhibit the expression of IL-1 receptor in chondrocytes. 3, inhibit the activity of IL-1. 4, inhibit the generation of metalloproteinases and peroxides such as collagenase and matrix lysin. 5, promote the synthesis of collagen and aminopolysaccharide. 6, inhibit the chemotaxis of leukocytes and stabilize lysosomes. Diacetate does not change the epoxidase activity of kidneys and platelets, and does not inhibit prostaglandins and formation, so patients with prostaglandin-dependent renal dysfunction can tolerate it. oral administration of 50mg,PPB is 99%,Tmax is 2.2 h,Cmax is 3.2 mg/L,AUC is 21.3 mg h/L, T1/2β is 4.3 h. Serving with food can increase the Tmax and AUC values of this product. adverse reactions: diarrhea, abdominal pain and soft stool may occur in 50% patients. |
| effect | diacerein and its metabolite rhein can inhibit the production and activity of urokinase-type plasminogen activator (u-PA), directly reduce osteoblast synthesis, reduce osteocalcin and promote bone mineralization. |
| use | widely used in new liquid crystal polymers, high-strength fibers with excellent performance and engineering plastics this product is an important inhibitor of osteoarthritis IL-1. Used for osteoarthritis natural antioxidant has the effects of delaying aging, enhancing immunity, clearing sub-health state, restoring physical fitness, improving energy and body immunity, etc. an interleukin-1β inhibitor, which is a slow-acting anthraquinone compound. |
CAS:
13739-02-1
MF:
C19H12O8
MW:
368.29
EINECS:
237-310-2
MDL No.:
MFCD00468030
Melting point:
217-2180C
Boiling point:
631.5±55.0 °C(Predicted)
Density
1.491±0.06 g/cm3(Predicted)
storage temp.
Sealed in dry,Room Temperature
solubility
DMSO (Sparingly), Methanol (Slightly)
pka
3.01±0.20(Predicted)
color
Light Yellow to Yellow
Water Solubility
240μg/L at 25℃
Merck
14,2960
InChIKey
TYNLGDBUJLVSMA-UHFFFAOYSA-N
LogP
3.126 (est)
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.