Xi`an Eastling Biotech Co., Ltd.
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China (Mainland)
Business Type:Lab/Research institutions
Tel: +86-156-91766041
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Tel: +86-156-91766041
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URL: http://www.eastlingbiotech.com/
Province/state: Shaanxi
City: Xi'an city
Street: No. 201, Unit 4, Building 9, Hongqi Community, Tanjia Street, Weiyang District, Xi 'an, Shaanxi
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CAS NO.1353224-53-9
99%(1-25)Kilogram
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.
In studies conducted on HT22 cells, CMS-121 has demonstrated significant neuroprotective effects. It effectively protects these cells from ischemia and oxidative damage. The ability of CMS-121 to protect neuronal cells suggests its potential in combating ischemic diseases and oxidative stress-induced neurological disorders. Additionally, CMS-121 exhibits significant anti-inflammatory properties, indicating its ability to modulate inflammatory responses. By doing so, CMS-121 has the potential to reduce inflammation in various tissues and organs, potentially treating inflammatory diseases. Additionally, CMS-121 has potent antioxidant activity that can counteract damage caused by oxidative stress. Preliminary studies in rapidly aging SAMP8 mice show promising results with CMS-121. Oral administration of CMS-121 over 4 months reduced cognitive decline, improved metabolic markers, and attenuated transcriptional markers associated with brain aging. Additionally, CMS-121 was found to maintain mitochondrial homeostasis by regulating acetyl-CoA metabolism.
(1) Effective activity: CMS-121 has strong pharmacological activity as an inhibitor of acetyl-CoA carboxylase 1 (ACC1). Its potent inhibitory effect on ACC1 makes it a promising compound for various therapeutic applications.
(2) Neuroprotective effect: CMS-121 exhibits significant neuroprotective properties and protects HT22 cells from ischemia and oxidative damage. This neuroprotective activity suggests its potential in the treatment of neurological disorders characterized by such injuries.
(3) Anti-inflammatory activity: CMS-121 exhibits significant anti-inflammatory effects, indicating its ability to regulate inflammatory responses. This property opens up the possibility of treating inflammatory diseases, where modulation of inflammation is crucial.
(4) Antioxidant activity: CMS-121 has strong antioxidant activity and can resist damage caused by oxidative stress. This antioxidant capacity has the potential to address diseases associated with oxidative stress.
CMS-121 is a quinolone derivative and orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor with promising pharmacological properties. Extensive research has been conducted to investigate the potential benefits of CMS-121 in various areas, including neuroprotection, anti-inflammatory effects, antioxidant activity and its effects on aging-related markers. This compound shows great potential as a therapeutic agent for the treatment and prevention of neurological disorders, cognitive decline, and age-related diseases.