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CAS NO.120287-85-6
98%(500-1000)Kilogram98%(100-500)Metric Ton
Cetrorelix
CAS: 120287-85-6
Molecular Formula: C70H92ClN17O14
| Name | Cetrorelix |
| Synonyms | CETRORELIX Cetrorelix Cetrorelixum CETRORELIX ACID Cetrorelix [INN] Cetrorelix acetate CETRIZINEDIHYDROCHLORIDE Cetrorelixum [inn-latin] AC-(D-ALA[3-(2-NAPHTHYL)])-[D-PHE(4-CL)]-(D-ALA[3-(3-PYRIDYL)])-SER-TYR-(D-CIT)-LEU-ARG-PRO-D-ALA-OH N-Acetyl-3-(2-naphthalenyl)-D-Ala-4-chloro-D-Phe-3-(3-pyridyl)-D-Ala-L-Ser-L-Tyr-N5-(aminocarbonyl)-D-Orn-L-Leu-L-Arg-L-Pro-D-Ala-NH2 N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(pyridin-3-yl)-D-alanyl-L-seryl-L-tyrosyl-N~5~-carbamoyl-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide D-alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N~5~-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl- (2S)-N-[(2R)-1-Amino-1-oxopropan-2-yl]-1-[(2S,5S,8R,11S,14S,17R,20R,23R)-2-(3-carbamimidamidopropyl)-8-[3-(carbamoylamino)propyl]-20-(4-chlorobenzyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-5-isobutyl-23-(2-naphthylmethyl)-4,7,10,13,16,19,22,25-octaoxo-17-(pyridin-3-ylmethyl)-3,6,9,12,15,18,21,24-octaazahexacosan-1-oyl]pyrrolidine-2-carboxamide (non-preferred name) |
| CAS | 120287-85-6 |
| EINECS | 686-384-6 |
| InChI | InChI=1/C70H92ClN17O14/c1-39(2)31-52(61(94)82-51(15-9-28-77-69(73)74)68(101)88-30-10-16-58(88)67(100)79-40(3)59(72)92)83-60(93)50(14-8-29-78-70(75)102)81-63(96)54(34-43-20-25-49(91)26-21-43)86-66(99)57(38-89)87-65(98)56(36-45-11-7-27-76-37-45)85-64(97)55(33-42-18-23-48(71)24-19-42)84-62(95)53(80-41(4)90)35-44-17-22-46-12-5-6-13-47(46)32-44/h5-7,11-13,17-27,32,37,39-40,50-58,89,91H,8-10,14-16,28-31,33-36,38H2,1-4H3,(H2,72,92)(H,79,100)(H,80,90)(H,81,96)(H,82,94)(H,83,93)(H,84,95)(H,85,97)(H,86,99)(H,87,98)(H4,73,74,77)(H3,75,78,102)/t40-,50-,51+,52+,53-,54-,55+,56-,57-,58 /m1/s1 |
| Molecular Formula | C70H92ClN17O14 |
| Molar Mass | 1431.04 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Melting Point | >259°C (dec.) |
| Solubility | DMSO (Slightly, Heated), Methanol (Very Slightly) |
| Appearance | White powder |
| Color | White to Off-White |
| pKa | 9.82±0.15(Predicted) |
| Storage Condition | Refrigerator |
| Refractive Index | 1.667 |
| overview | cetrorelix acetate is a synthetic decapeptide, which is mainly used in assisted reproductive technology to prevent early ovulation for patients with controlled ovarian stimulation. cetrorelix acetate is also often called cetrorelix, which is a gonadotropin-releasing hormone (GnRH) antagonist, it can compete with endogenous LHRH to bind receptors on the pituitary cell membrane, thereby inhibiting the secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the pituitary in a dose-dependent manner. |
| pharmacological effects | cetrorelix acetate is a gonadotropin-releasing hormone (GnRH) antagonist. This product competes with endogenous GnRH for receptors on pituitary cells, thereby inhibiting the release of endogenous luteinizing hormone (LH) and follicle stimulating hormone (FSH), delaying the appearance of LH peaks, thereby controlling ovulation. The effect of this product is dose-dependent, the inhibitory effect is direct, and it is maintained by continuous treatment, and it does not cause the luteinizing hormone receptor activity to rise at the beginning and then down-regulated. |
| application | cetrorelix acetate is a synthetic decapeptide, which is mainly used in assisted reproductive technology to prevent premature ovulation for patients with controlled ovarian stimulation. cetrorelix acetate is also often called cetrorelix, which is a gonadotropin-releasing hormone (GnRH) antagonist, it can compete with endogenous LHRH to bind receptors on the pituitary cell membrane, thereby inhibiting the secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the pituitary in a dose-dependent manner. |
| detection method | step 1, weigh cetrorrik acetate, dissolve with acetonitrile, dilute with acetonitrile and sulfate buffer solution to prepare impurity reference substance solution; Step 2, weigh cetrorrik acetate, add acetonitrile to dissolve, and dilute with acetonitrile and sulfate buffer solution, prepare a solution containing cetrorelix; step 3, take the impurity reference solution and the test solution respectively and inject it into the liquid chromatograph, record the chromatogram, and calculate the content of each impurity by the peak area according to the external standard method; this method Effectively solve the problem of separating the related substances of its preparation. This method has strong specificity and good repeatability, and can ensure the controllability of the related substances in its preparation. |
| effect | cetrorelix acetate (cetrorelixAcetate), also commonly known as cetrorelix, is an effective progesterone releasing hormone inhibin (LH-RH) receptor antagonist, which can control ovarian stimulation, prevent premature discharge of immature follicles and help conception, so it is often used as a preparation for injection. |
Mol Download Chemical properties
CAS:
120287-85-6
MF:
C70H92ClN17O14
MW:
1431.04
EINECS:
686-384-6
MDL No.:
MFCD00884467
Melting point:
>259°C (dec.)
Density
1.42±0.1 g/cm3(Predicted)
storage temp.
Refrigerator
solubility
DMSO (Slightly, Heated), Methanol (Very Slightly)
form
Solid
pka
9.82±0.15(Predicted)
color
White to Off-White
InChIKey
SBNPWPIBESPSIF-MHWMIDJBSA-N
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
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