Xi`an Eastling Biotech Co., Ltd.
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CAS NO.10597-60-1
98%(1-25)Kilogram98%(26-500)Kilogram98%(501-1000)Kilogram
| Molecular Formula | C8H10O3 |
| Molar Mass | 154.16 |
| Density | 1.321±0.06 g/cm3(Predicted) |
| Boling Point | 355.4±27.0 °C(Predicted) |
| Flash Point | 182.6°C |
| Solubility | Soluble in methanol, DMSO and other solvents, insoluble in petroleum ether, ether, chloroform. |
| Vapor Presure | 1.15E-05mmHg at 25°C |
| Appearance | Pale yellow liquid |
| Color | Colourless to Yellow Sticky Oil to |
| BRN | 2208118 |
| pKa | 9.72±0.10(Predicted) |
| Storage Condition | -20°C |
| Stability | Hygroscopic |
| Refractive Index | 1.5810-1.5860 |
| MDL | MFCD01320529 |
| Physical and Chemical Properties | Soluble in methanol, DMSO and other solvents, insoluble in petroleum ether, ether, chloroform. Leaves from the Oleaceae plant olive (Olea europaea) |
| In vitro study | Hydroxytyrosol (DOPET) shows the inhibition of pro-inflammatory cytokines (TNF-α) and reduces the expression of cyclooxygenase-2 and inducible nitric oxide synthase (iNOS) more than 60%. Hydroxytyrosol (DOPET) modulates the transcription factor NF-κB. Hydroxytyrosol (DOPET) arrests the cell cycle, producing differentiation, apoptosis, or preventing DNA from oxidative stress. |
| Plant source: | Olives |
| introduction of hydroxytyrosol | hydroxytyrosol is an active ingredient in olives and acts as a highly active antioxidant in the human body. Antioxidants are bioactive molecules in many plants, but their activities are not the same. Hydroxytyrosol is regarded as one of the most powerful antioxidants, and the market demand is increasing. Its oxygen radical absorption capacity is about 4,500,000 μmol TE/100g: 10 times that of green tea and more than 2 times that of CoQ10 and quercetin. Professor Liu Jiankang, Director of the Institute of Mitochondrial Biomedicine, Xi'an Jiaotong University Academy of Sciences, cooperated with the Swiss DSM Nutrition Products Company to systematically study the role of a polyphenol extract hydroxytyrosol in olive oil from the level of molecular biology. Research shows that this substance promotes the function of mitochondria by promoting mitochondrial synthesis, they found that the olive oil extract hydroxytyrosol (hydroxytyrosol) can effectively protect the oxidative damage of retinal pigment epithelial cells and mitochondrial dysfunction caused by the toxic component of acrolein in cigarettes. The main mechanism is that hydroxytyrosol can induce cells with detoxification. Two-phase enzyme system. These results suggest that hydroxytyrosol may have a protective effect on the degeneration of retinal pigment epithelial cells caused by smoking, such as retinal macular disease. The results also support that a diet rich in olive oil will be beneficial to the treatment of diseases related to mitochondrial dysfunction such as diabetes and obesity. Fig. 1 shows olive oil and polyphenol extract hydroxytyrosol white powder |
| Efficacy and effects | Hydroxytyrosol has anti-inflammatory effects, dilation of blood vessels and antibacterial effects, can prevent atherosclerosis, and can reduce certain cancers (such as breast, prostate, The incidence of endometrium, digestive tract); because hydroxytyrosol has strong antioxidant activity and reduces the incidence of cancer, it has a huge prospect of medical effects. |
| Application | Hydroxytyrosol has anti-inflammatory effects, dilation of blood vessels and antibacterial effects, can prevent atherosclerosis, and can reduce certain cancers (such as breast, prostate, The incidence of endometrium, digestive tract); because hydroxytyrosol has strong antioxidant activity and reduces the incidence of cancer, it has a huge medical prospect. Hydroxytyrosol is a metabolite of tyrosol and is also found in olive oil with strong antioxidant properties. |
| biological activity | Hydroxytyrosol (DOPET) is a phenolic compound extracted from olive trees and their leaves. it has antioxidant, anti-atherosclerosis, anti-thrombotic, antibacterial, anti-inflammatory and anti-tumor effects. |
| use | 1. hydroxytyrosol is used in cardiovascular drugs, which is effective in the prevention and treatment of arteriosclerosis, hypertension, heart disease, cerebral hemorrhage, etc. It is better than similar drugs. 2. Hydroxytyrosol, as a safe and efficient antioxidant, is applied to beauty products and health products, which can effectively enhance skin elasticity and moisturizing, and has the effect of removing wrinkles and anti-aging. 3. Hydroxytyrosol is beneficial to the skeletal system: it helps the human body to absorb minerals, without calcium supplementation, natural absorption, maintains bone density, reduces osteoporosis, and improves endocrine system function, promotes metabolism, and promotes wound healing. Eliminate free radicals in the body, restore the health of the human viscera and organs, prevent brain failure, delay aging, and maintain youthful vitality. 4. Application of hydroxytyrosol in anti-cancer and anti-cancer: it can prevent and treat lung cancer, breast cancer, uterine metabolites of oleuropein. Antioxidants. Inhibit the proliferation rate of cancer cells and induce apoptosis of cancer cells. |
CAS:
10597-60-1
MF:
C8H10O3
MW:
154.16
EINECS:
600-704-3
MDL No.:
MFCD01320529
Boiling point:
355.4±27.0 °C(Predicted)
Density
1.321±0.06 g/cm3(Predicted)
refractive index
1.5810-1.5860
storage temp.
-20°C
solubility
Acetonitrile (Slightly), DMSO (Slightly), Ethyl Acetate (Sparingly), Methanol (Slightly)
form
Solid
pka
9.72±0.10(Predicted)
color
Colourless to Yellow Sticky Oil
BRN
2208118
Stability:
Hygroscopic
InChI
InChI=1S/C8H10O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,9-11H,3-4H2
InChIKey
JUUBCHWRXWPFFH-UHFFFAOYSA-N
SMILES
C1(O)=CC=C(CCO)C=C1O
LogP
0.020 (est)
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.