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CAS NO.491-67-8
98%(1-25)Kilogram98%(26-500)Kilogram98%(501-1000)Kilogram
Baicalein
CAS: 491-67-8;27462-75-5
Molecular Formula: C15H10O5
| Name | Baicalein |
| Synonyms | Noroxylin Baicalein Baicelein Baicaleine 5,6,7-Trihydroxyflavone BAICALEIN(SH)NOW RG GRADE 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one 5,6,7-trihydroxy-2-phenyl-4H-chroMen-4-one 5,6,7-trihydroxy-2-phenyl-4-chromenone hydrate 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one hydrate Baicalein, monohydrate, 5,6,7-Trihydroxy-2-phenyl-4H-chromen-4-one monohydrate |
| CAS | 491-67-8 27462-75-5 |
| EINECS | 000-000-0 |
| InChI | InChI=1/C15H10O5.H2O/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12;/h1-7,17-19H;1H2 |
| InChIKey | FXNFHKRTJBSTCS-UHFFFAOYSA-N |
| Molecular Formula | C15H10O5 |
| Molar Mass | 270.24 |
| Density | 1.3280 (rough estimate) |
| Melting Point | 256-271 °C (lit.) |
| Boling Point | 373.35°C (rough estimate) |
| Specific Rotation(α) | -14°(water)；-139°(pyridine) |
| Flash Point | 347°C |
| Solubility | Soluble in methanol, ethanol, acetone, ethyl acetate and hot glacial acetic acid, slightly soluble in chloroform, soluble in dilute sodium hydroxide is green brown, but unstable, easy to oxidize to green. |
| Vapor Presure | 8.55E-18mmHg at 25°C |
| Appearance | Yellow needle crystal (ethanol) |
| Color | Yellow or yellow-green |
| Merck | 14,942 |
| BRN | 272683 |
| pKa | 6.31±0.40(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week. |
| Sensitive | Sensitive to light and heat |
| Refractive Index | 1.5000 (estimate) |
| MDL | MFCD00017459 |
| Physical and Chemical Properties | Yellow prismatic crystals (from ethanol). Melting point 264~265 °c (decomposition). Soluble in ethanol, methanol, ether, acetone, ethyl acetate, hot glacial acetic acid, slightly soluble in chloroform and nitrobenzene, almost insoluble in water, soluble in dilute sodium hydroxide green Brown, concentrated sulfuric acid yellow and green fluorescence. It can also be synthesized chemically in the root of Scutellaria baicalensis Georgi, and in the seed and stem bark of the echinaceae plant xylem indicum (L.)Vent. |
| Use | With anti-inflammatory, anti-allergic, diuretic, choleretic, cholesterol-lowering, anti-thrombosis, relieve asthma and other effects. It is also a specific inhibitor of mammalian liver salivary enzymes and has a role in the regulation of certain diseases. Industrial raw materials for the preparation of baicalin original phosphate for allergy, asthmatic Pneumonia, also as astringent, hemostatic. |
| pharmacological activity | baicalein, also known as baicalin yuan, is an important pharmacodynamic active ingredient in traditional Chinese medicine scutellaria baicalensis (ScutellariabaicalensisGeorge) and wood butterfly (Oroxylumindicum), with significant antioxidant, anti-inflammatory, anti-allergic, antibacterial, antiviral, anti-tumor and other pharmacological activities. |
| Biological activity | Baicalein are CYP2C9 and prolyl endopeptidase inhibitors. |
| Target | Value |
| Uses | A flavonoid compound that is a xanthine oxidase inhibitor. It has anti-inflammatory, anti-allergic, diuretic, choleretic, cholesterol-lowering, anti-thrombosis, and asthma relief. It is also a specific inhibitor of salivary enzymes in mammalian liver, which has the effect of regulating certain diseases. In industry, baicalin protophosphate is prepared from it as a raw material for allergies and asthmatic pneumonia, as well as astringents and hemostatic drugs. |
| production method | 1. extract scutellaria baicalensis root, pulverize and boil with water for 3 times, combine the extracts, add acid to adjust the ph value to 4 after filtration, stir with slight heat, stand still, centrifuge to separate the precipitate. The sediment is washed with water with a ph of 4 and dried to produce crude products. The crude product is refluxed and hydrolyzed in 1.2 mol · L-1 hydrochloric acid with boiling water for several hours, and the precipitated product is scutellarin by cooling and filtering. |
CAS:
491-67-8
MF:
C15H10O5
MW:
270.24
EINECS:
000-000-0
MDL No.:
MFCD00017459
Melting point:
256-271 °C (lit.)
Boiling point:
373.35°C (rough estimate)
Density
1.3280 (rough estimate)
refractive index
1.5000 (estimate)
storage temp.
Keep in dark place,Sealed in dry,2-8°C
solubility
DMSO (Slightly), Methanol (Slightly)
pka
6.31±0.40(Predicted)
form
Yellow solid
color
Yellow or yellow-green
Merck
14,942
BRN
272683
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
InChIKey
FXNFHKRTJBSTCS-UHFFFAOYSA-N
LogP
3.310 (est)
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.