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CAS NO.478-01-3
98%(1-25)Kilogram98%(26-500)Kilogram98%(501-1000)Kilogram
Nobiletin
CAS: 478-01-3
Molecular Formula: C21H22O8
| Name | Nobiletin |
| Synonyms | biletin NOBILETIN Nobiletin NSC 76751 CCRIS 9012 Chuanpi glycosides Hexamethoxyflavone 3',4',5,6,7,8-HEXAMETHOXYFLAVONE Nobiletin, froM Citrus nobilis Lour. 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy- |
| CAS | 478-01-3 |
| InChI | InChI=1/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3 |
| InChIKey | MRIAQLRQZPPODS-UHFFFAOYSA-N |
| Molecular Formula | C21H22O8 |
| Molar Mass | 402.39 |
| Density | 1.244±0.06 g/cm3(Predicted) |
| Melting Point | 136.0 to 140.0 °C |
| Boling Point | 587.9±50.0 °C(Predicted) |
| Flash Point | 256.5°C |
| Solubility | Soluble in DMSO, chloroform and methanol, slightly soluble in water and ether, insoluble in petroleum ether. |
| Vapor Presure | 8.39E-14mmHg at 25°C |
| Appearance | Colorless crystal |
| Color | White |
| BRN | 360887 |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Sensitive | Sensitive to heat |
| Refractive Index | 1.558 |
| MDL | MFCD03273560 |
| Physical and Chemical Properties | White crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from tangerine peel, lime peel, citrus, fructus aurantii. |
| In vitro study | Nobiletin, a citrus flavone isolated from citrus peels such as oranges, has anti-inflammatory and anti-tumor activities. Nobiletin, a polymethoxyflavone, can inhibit NO and O tumor invasion activity of human fibrosarcoma HT-1080 cells in an artificial basement membrane model, not only by inhibiting the expression of MMPs, it also acts by interfering with the phosphatidylinositol 3-kinase pathway (PI3-K) to increase the production of TIMP-1. Nobiletin may also prevent atherosclerosis at the level of the vessel wall by inhibiting the formation of macrophage cavernous cells. |
| In vivo study | LD50: 780 mg/kg (I. g.). |
| biological activity | Nobiletin (Hexamethoxyflavone) is O-methyl flavone, a flavonoid compound isolated from citrus peel such as orange. It has anti-inflammatory and anti-tumor activities. |
| Target | Value |
| uses | nobiletin has the effects of anti-hemagglutination, anti-thrombosis, anti-cancer, anti-fungal, anti-inflammatory, anti-inflammatory, anti-virus, anti-cancer, anti-mutation, anti-allergy, anti-ulcer, analgesic, blood pressure lowering activity and blood cholesterol lowering. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: anti-hemagglutination, anti-thrombosis, anti-cancer, anti-fungal, anti-inflammatory, anti-allergic, anti-cholinesterase and anti-epileptic effects, carbohydrate metabolism promoter |
Mol Download Chemical properties
CAS:
478-01-3
MF:
C21H22O8
MW:
402.39
EINECS:
251-228-4
MDL No.:
MFCD03273560
Melting point:
136.0 to 140.0 °C
Boiling point:
587.9±50.0 °C(Predicted)
Density
1.244±0.06 g/cm3(Predicted)
storage temp.
Sealed in dry,Store in freezer, under -20°C
solubility
Soluble in DMSO (up to 10 mg/ml)
color
White
BRN
360887
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey
MRIAQLRQZPPODS-UHFFFAOYSA-N
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.