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CAS NO.16830-15-2
98%(1-25)Kilogram98%(26-500)Kilogram98%(501-1000)Kilogram
| Molecular Formula | C48H78O19 |
| Molar Mass | 959.12 |
| Density | 1.44±0.1 g/cm3(Predicted) |
| Melting Point | 235-238°C |
| Boling Point | 1017.5±65.0 °C(Predicted) |
| Specific Rotation(α) | D20 -14° (alc) |
| Water Solubility | 99mg/L |
| Solubility | DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated), Methanol (Slightly) |
| Vapor Presure | 0.001Pa at 160℃ |
| Appearance | Pale yellow crystal |
| Color | Crystals |
| pKa | 12.50±0.70(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.606 |
| MDL | MFCD06642601 |
| Physical and Chemical Properties | White crystalline powder, soluble in water, ethanol, insoluble in ether, chloroform, from Centella asiatica. |
| Use | Promote wound healing, stimulate the growth of granulation, treatment of various skin diseases |
| plant source: | asiatica |
| LogP | 0.44 at 22℃ |
| pharmacological effects | century asiatica is the dry whole grass or root whole grass of the Umbelliferae plant (Centellaasiatica(L)Urban), also known as Lei Gonggen, horseshoe grass, which can be harvested all the year round and is rich in resources. It has grown in Southeast Asia, Australia, South Africa and tropical Central Africa and has a long history of application in the field of medicine in many countries. The asiatica is cold in nature and bitter in taste. It has the effects of clearing heat and dampness, detoxification and detumescence. It is mainly used for damp-heat jaundice, heatstroke diarrhea, carbuncle swelling poison, and bruises. asiaticoside (Asiaticoside) belongs to pentacyclic triterpenoids, which has many pharmacological effects such as anti-ulcer, promoting wound healing, anti-tumor, anti-inflammatory, immune regulation, etc. At present, it is mainly used to treat scleroderma and skin trauma and burns. |
| mechanism of action | asiaticoside can act on the nucleus of fibroblasts, reducing the mitotic phase and reducing or missing the nucleolus. With the increase of drug concentration, intracellular DNA synthesis is reduced, cell growth is in an inhibited state, and the inhibition rate can reach up to 73%, suggesting that the mechanism of asiaticoside is to block the proliferation of fibroblasts, so as to reduce the synthesis of collagen and prevent scar hyperplasia. |
| application | asiaticoside (Asiaticoside) is the main component of asiaticoside. the mixture of asiaticoside a and asiaticoside B has pharmacological effects such as promoting wound healing, anti-wrinkle, anti-inflammatory, anti-depression and promoting intelligence. Comparing the pharmacological effects of asiaticoside on promoting wound healing and treating scars, it can be found that the anti-inflammatory, anti-depressant, and intelligence-promoting pharmacological effects of asiaticoside A and asiaticoside B may play a major role. |
| preparation method | weigh 500g of crushed snow grass powder, soak it in 2500ml of 75% ethanol aqueous solution, extract it by ultrasonic wave for 4 times at 50 ℃ for 1 hour each time, and concentrate the filtrate under reduced pressure to obtain 20.5g of extract. Dissolve the extract with 200ml of water, and extract it for 3 times with petroleum ether of the equal volume of the extract aqueous solution, the lower phase aqueous solution is then extracted 4 times with equal volume of ethyl acetate, and the lower phase aqueous solution is collected. The volume ratio of n-butanol and ethyl acetate of the same volume of the pooled lower phase aqueous solution is 1: 1 mixed solvent for extraction for 3 times, the upper phase extract is combined, the activated carbon decolorized extract is used, and the decolorized extract is concentrated under reduced pressure to obtain the total glucoside of centella asiatica 7.3g; Add 10 times the amount of methanol to dissolve the total glucoside of centella asiatica, filter, concentrate the filtrate, and recrystallize with an ethanol aqueous solution with a mass concentration of 90% at room temperature, the purity is 90% and the yield is 0.66%. |
| use | promote wound healing, stimulate granulation growth, treat various skin diseases promote wound healing, stimulate granulation growth, treat various skin diseases. |
| category | toxic substances |
| flammability hazard characteristics | combustible; combustion produces stimulating smoke |
| storage and transportation characteristics | ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
Mol Download Chemical properties
CAS:
16830-15-2
MF:
C48H78O19
MW:
959.12
EINECS:
240-851-7
MDL No.:
MFCD31657273
Melting point:
235-238°C
alpha
D20 -14° (alc)
Boiling point:
1017.5±65.0 °C(Predicted)
Density
1.44±0.1 g/cm3(Predicted)
vapor pressure
0.001Pa at 160℃
storage temp.
under inert gas (nitrogen or Argon) at 2-8°C
solubility
DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated), Methanol (Slightly)
pka
12.50±0.70(Predicted)
color
Crystals
Water Solubility
99mg/L
InChIKey
WYQVAPGDARQUBT-KRQXBQLUNA-N
LogP
0.44 at 22℃
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.