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CAS NO.1077-28-7
98%(500-1000)Kilogram98%(100-500)Metric Ton
Alpha lipoic acid USP grade
| introduction | DL-lipoic acid is a unique anti-free radical substance, usually called a wide range of antioxidants. It is a vitamin-like substance produced in the body. Unlike other antioxidants with special effects produced in the body, DL-lipoic acid is neither strictly fat-soluble nor water-soluble, which allows it to promote the activity of other antioxidants in the body, and it is also widely available when antioxidants are insufficient. Substitute. For example, if the vitamin C and vitamin E stored in the body are very low, DL-lipoic acid can be temporarily supplemented. Because DL-lipoic acid can pass through the blood-brain barrier, it can help reverse the adverse reactions caused by stroke. DL-lipoic acid also helps maintain normal blood sugar levels and prevent serious complications of diabetes. With age, the human body will not be able to make sufficient DL-lipoic acid to maintain health. If it's over forties. Then don't miss the opportunity to supplement DL-lipoic acid. Commercially available DL-lipoic acid is a tablet or an antioxidant formulation product containing DL-lipoic acid. It is recommended to take 1~2 tablets of 50mg DL-lipoic acid every day. |
| use | α-lipoic acid is also a highly effective antioxidant and plays an important role in the prevention and treatment of many diseases. Vitamin drugs can stimulate fat metabolism. For the treatment and curative effect of acute and chronic hepatitis, liver cirrhosis, hepatic coma, fatty liver, diabetes and other diseases antioxidants and as pyruvate dehydrogenase (pyruvate dehydrogenase) and glycine decarboxylase (glycine decarboxylase) coenzyme, exogenous lipoic acid is reduced by two or more enzymes in the cell. This reduced form affects the process of cell scavenging free radicals. Increase glutathione (glutathione) synthesis and regulate transcription factor activity. Decreased phagocytosis of macrophage myelin. |
| Biochemical function | DL-lipoic acid can transfer hydrogen and become an antioxidant through mutual transformation between oxidized and reduced types. The human body can synthesize the required DL-lipoic acid. At present, no deficiency of DL-lipoic acid has been found. DL-lipoic acid (1ipoic acid) is a sulfur-containing octa-carbon fatty acid, which exists in two forms: oxidized and reduced. In nature, DL-lipoic acid is bound to protein, and its carboxyl group is the lysine in the protein molecule-NH. Connect. DL-lipoic acid is an acyl carrier, which exists in pyruvate dehydrogenase and a ketoglutarate dehydrogenase and is closely related to sugar metabolism. The oxidized and reduced DL-lipoic acid interconversion acids have the function of coupling acyl transfer and electron transfer during the oxidation and decarboxylation of a keto acid. DL-lipoic acid is widely distributed in nature, especially abundant in liver and yeast. It often exists in food at the same time as vitamin B. |
| application | in the field of medicine, α-lipoic acid is widely used in the prevention and adjuvant treatment of diabetes and its related complications. It can enhance glucose metabolism, reduce oxidative stress, relieve diabetic neuropathy symptoms, prevent diabetic cataract, and prevent diabetic cardiovascular damage. |
| Biological activity | Thioctic acid (DL-α-Lipoic acid) is a cyclic disulfide antioxidant that can be converted to its reducing disulfide phenol form. |
Certificate
ISO22000/USDA Organic/EU Organic/HALAL/KOSHER/HPCCA
Stock
In Stock
Shelf Life
24 Months
Packaging and delivery
Packaging Details
1. 1 kilogram per aluminum foil bag with one plastic-bags inside;
2. 25 kilograms per cardboard barrel with one plastic-bags inside;
3. Packaging as the customers' requirements.
DL-Lipoic acid
CAS: 1077-28-7
Molecular Formula: C8H14O2S2
| Name | DL-Lipoic acid |
| Synonyms | THIOOCTIC ACID DL-Lipoic acid DL-Thioctic acid DL-6-Thioctic acid TIMTEC-BB SBB003484 DL-alpha-Lipoic acid (1)-ALPHA-LIPOIC ACID DL-6,8-Dithiooctanoic acid dl-1,2-Dithiolane3-valericacid 5 MG PNPP SUBSTRATE TABLETS REAGENT GR 5-(1,2)Dithiolan-3-yl-pentanoic acid for synthesis |
| CAS | 1077-28-7 |
| EINECS | 214-071-2 |
| InChIKey | AGBQKNBQESQNJD-UHFFFAOYSA-N |
| Molecular Formula | C8H14O2S2 |
| Molar Mass | 206.33 |
| Density | 1.2888 (rough estimate) |
| Melting Point | 60-62°C |
| Boling Point | 160-165°C(lit.) |
| Flash Point | 160-165°C |
| Water Solubility | 0.9 g/L (20 ºC) |
| Solubility | Soluble in benzene, methanol, ethanol, slightly soluble in petroleum ether, almost insoluble in water |
| Appearance | Yellow crystalline powder |
| Color | Yellow |
| Merck | 14,9326 |
| BRN | 81853 |
| pKa | 4.75±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Sensitive | Sensitive to light |
| Refractive Index | 1.5200 (estimate) |
| MDL | MFCD00005474 |
| Physical and Chemical Properties | The appearance of alpha-lipoic acid is pale yellow powder crystals, almost tasteless, the chemical structure is 6,8 one or two DL-lipoic acid, in 6,8 between carbon disulfide bonds to form internal disulfide compounds. When reduced, the disulfide bond breaks to form dihydrodl-lipoic acid. Alpha-lipoic acid is insoluble in water but soluble in lipid solvents, which is listed as a fat-soluble vitamin; It is soluble in methanol, ethanol, chloroform, ether. |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | The long terminal repeat (LTR) of HIV-1 is the target of cellular transcription factors such as NF-κB, and serves as the promoter-enhancer for the viral genome when integrated in host DNA. α-Lipoic Acid (Alpha-Lipoic acid, ALA), a naturally occurring dithiol compound, plays an essential role in mitochondrial bioenergetics. α-Lipoic Acid reduces lipid accumulation in the liver by regulating the transcriptional factors SREBP-1, FoxO1, and Nrf2, and their downstream lipogenic targets via the activation of the SIRT1/LKB1/AMPK pathway. Treatment of cells with α-Lipoic Acid (250, 500 and 1000 μM) significantly increases the NAD + /NADH ratio in HepG2 cells (P<0.05 or P<0.01). Treatment with α-Lipoic Acid (50, 125, 250 and 500 μM) increases SIRT1 activity in HepG2 cells. α-Lipoic Acid (50, 125, 250, 500 and 1000 μM) increases phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in HepG2 cells in a dose-dependent fashion. |
| In vivo study | C57BL/6J mice, divided into four groups, are fed an high-fat diet (HFD) for 24 weeks to induce nonalcoholic fatty liver disease (NAFLD) followed by daily administration of α-Lipoic Acid. Then, the effects of α-Lipoic Acid on hepatic lipid accumulation in long-term HFD-fed mice are assessed. Administration of α-Lipoic Acid (100 mg/kg or 200 mg/kg) markedly reduces visceral fat mass in mice. In addition, α-Lipoic Acid (100 mg/kg or 200 mg/kg) treatment inhibits the appetite and causes a dramatic weight loss (all P<0.05). |
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.