Xi`an Eastling Biotech Co., Ltd.
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City: Xi'an city
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CAS NO.33515-09-2
98%(500-1000)Kilogram98%(100-500)Metric Ton
CAS: 9034-40-6;33515-09-2
Molecular Formula: C55H75N17O13
| Molecular Formula | C55H75N17O13 |
| Molar Mass | 1182.29 |
| Density | 1.1147 (rough estimate) |
| Boling Point | 834.95°C (rough estimate) |
| Specific Rotation(α) | D25 -50° (1% acetic acid) |
| Storage Condition | -15°C |
| Refractive Index | 1.6200 (estimate) |
| Hazard Symbols | T - Toxic |
| Risk Codes | 60 - May impair fertility |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| Toxicity | LD50 oral in rat: > 3gm/kg |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Overview | Luteinizing hormone-releasing hormone is also known as luteinizing hormone-releasing hormone, referred to as LRH or LH-RH. A hormone secreted by the hypothalamus of fish and other vertebrates that stimulates the release of luteinizing hormone (LH) from the pituitary gland. It is secreted by the lateral nodular nucleus and preoptic nucleus nerve cells of the hypothalamus, and is transmitted to the pituitary gland through the axons or through the blood, which not only stimulates the release of luteinizing hormone, but also releases filtration (egg) vesicle hormone (FSH), Thereby promoting gonadal development, maturation and ovulation. LRH is a synthetic product 10 peptide, which has high biological activity on cattle, sheep, pigs, rats and humans, but has low effect on fish. Changing the configuration of LRH and synthesizing 9 peptide analogs (LRH-A) have high biological activity on grass carp, herring, silver carp, bighead carp, carp, etc., and have become a widely used fish prolific agent in China. |
| secretion mode | two secretion modes of LHRH: ① persistent microbasal secretion. Although this secretion mode cannot stimulate the release of GTH, it has a pre-excitation effect on LHRH itself and its receptor. ② intermittent pulse release. This mode of stimulation is the key to stimulate the synchronous release of LH with it. For the first time, it is confirmed by continuous and frequent blood collection and determination of LHRH and LH content in ovariectomized monkeys. |
| application | LHRH regulates the secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) in pituitary gland. The structural elucidation and artificial synthesis of hypothalamic LHRH have clarified the control of the central nervous system on the pituitary gland and greatly promoted the development of neuroendocrinology and reproductive physiology. In order to find non-steroidal contraceptives and treat sex hormone-dependent cancers (such as prostate cancer and uterine cancer), people have synthesized more than 5000 LHRH analogs, of which a few are agonists (agonists) and most are antagonists (antagonists). Highly active LHRH agonists are used to treat cancer and as contraceptives. Products are already on the market. LH-RH and its derivatives have the activity of promoting gonadotropin secretion. Sequential administration of LH-RH and its derivatives can inhibit gonadal function, so they can be used as drugs to inhibit and/or treat diseases such as endometriosis, central precocious puberty, infertility and prostate cancer. |
Mol Download Chemical properties
CAS:
33515-09-2
MF:
C55H75N17O13
MW:
1182.31
EINECS:
251-553-1
MDL No.:
MFCD00167538
Density
1.54
solubility
≥118.2 mg/mL in DMSO with ultrasonic; insoluble in EtOH; ≥28.7 mg/mL in H2O
pka
9.82±0.15(Predicted)
InChIKey
XLXSAKCOAKORKW-AQJXLSMYSA-N
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.