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CAS NO.300-08-3
1(2-5)Gram1(2-5)Gram2(2-5)Gram
| Molecular Formula | C8H14BrNO2 |
| Molar Mass | 236.11 |
| Melting Point | 171-175°C |
| Boling Point | 209°C at 760 mmHg |
| Flash Point | 81.1°C |
| Solubility | H2O: 0.1g/mL, clear, colorless |
| Vapor Presure | 0.208mmHg at 25°C |
| Appearance | Powder |
| Color | White to light yellow |
| Merck | 14,778 |
| BRN | 3914826 |
| pKa | 6.84(at 25℃) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions are not stable – make fresh daily. |
| Physical and Chemical Properties | This product is white or light yellow crystalline powder; Odorless, bitter taste. It is soluble in water and ethanol, slightly soluble in chloroform and ether, and the aqueous solution is relatively stable. It should be stored in a container protected from light. |
| Overview | Arecoline is an alkaloid in the seeds of the plant areca nut, and its hydrobromide is commonly used clinically [1]. White crystalline powder, odorless, bitter, poisonous, deteriorated in case of light. Melting point 170- 171 ℃. Soluble in water and ethanol. It is obtained by the reaction of arecoline with hydrobromic acid ethanol solution. Intestinal insect repellent drugs are mostly used for veterinary treatment [2]. figure 1 arecoline hydrobromide tablets |
| research on antithrombotic effect | research on antithrombotic and thrombolytic effects of arecoline hydrobromide on thrombus in vivo and in vitro. Methods: The thrombolytic effect of arecoline hydrobromide in vitro was investigated by the dissolution of human blood clots and human platelet plasma clots in vitro. The anti-thrombotic effect of arecoline hydrobromide in vivo was investigated by the model of carrageenan-induced tail vein thrombosis in mice. Results: Arecoline hydrobromide can accelerate the dissolution of human blood clots and platelet plasma clots in vitro, and has a dose-dependent effect of ; it has the effect of anti-carrageenan-induced tail vein thrombosis in mice. Conclusion: Hydrobromic acid arecoline has antithrombotic effect in vivo and in vitro. |
| pharmacological action | arecoline hydrobromide has a strong paralyzing effect on tapeworm muscles, causing the worm body to lose the ability to cling to the intestinal wall. in addition, the muscarinic effect of the drug on the host strengthens intestinal peristalsis and increases secretion of digestive glands, which is conducive to the rapid elimination of paralytic worms. This product is effective for all tapeworms in dogs. It can also repel taenia, polycephalus and Echinococcus granulosus. It also has an repellent effect on avian tapeworms. |
| clinical application | is mainly used for taeniasis common in dogs and poultry. |
| usage and dosage | oral administration: one dose, per kilogram of body weight, 1.5-2 mg for dogs, 3 mg for chickens, 1-2 mg for ducks and geese. |
| adverse reactions and poisoning rescue | (1) the use of normal dose of arecoline hydrobromide has less adverse reactions to dogs, and vomiting, diarrhea, secondary coma and convulsion can obviously occur when overdose. The general poisoning dose can be as much as 8 times the therapeutic dose. (2) This product is not safe for cats, and it can make their bronchi secrete a large amount of mucus and cause cats to suffocate and die. (3) atropine can detoxify and relieve symptoms of this product. |
| precautions | (1) dogs should fast for 12 hours before medication. if they still do not defecate 2 hours after medication, they should be taken with saline to accelerate the elimination of paralysis. (2) chickens have strong tolerance to this product, followed by ducks and geese, equine animals are more sensitive, and cats are the most sensitive, so it is advisable not to use it. (3) Due to the high toxicity of this product, it has been banned in the United States. |
| drug combination | atropine: it can detoxify arecoline and relieve symptoms, and can be used to rescue arecoline poisoning. Choline-like drugs such as pilocarpine: the combination of the two can enhance the toxicity. Pumpkin seeds: The combination of arecoline and pumpkin seeds can repel naked head tapeworm. |
| References | [1] Wang Kunhua, edited by Yang Zhikang. Guidelines for rational clinical application of veterinary drugs. Kunming: Yunnan Science and Technology Press. 2010. [2] Ma Shichang editor-in-chief. Dictionary of organic compounds. Xi'an: Shaanxi Science and Technology Press. 1988. Page 284. [3] Tang Fei, Wang Hao, Liu Weijun. Study on antithrombotic effect of arecoline hydrobromide [J]. Chinese Journal of Hospital Pharmacy, 2009,29(10):791-793. |
| use | for content determination/identification/pharmacological experiments, etc. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | subcutaneous-mouse LDL0: 65 mg/kg; Intravenous-mouse LD50: 18 mg/kg |
| flammability hazard characteristics | combustible; combustion produces toxic nitrogen oxides and hydrogen bromide smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
CAS:
300-08-3
MF:
C8H14BrNO2
MW:
236.11
EINECS:
206-087-3
MDL No.:
MFCD00039041
Melting point:
171-175 °C
storage temp.
Inert atmosphere,Room Temperature
solubility
H2O: 0.1 g/mL, clear, colorless
pka
6.84(at 25℃)
form
Powder
color
White to light yellow
Merck
14,778
BRN
3914826
Stability:
Stable for 2 years from date of purchase as supplied. Solutions are not stable – make fresh daily.
InChI
InChI=1S/C8H13NO2.BrH/c1-9-5-3-4-7(6-9)8(10)11-2;/h4H,3,5-6H2,1-2H3;1H
InChIKey
AXOJRQLKMVSHHZ-UHFFFAOYSA-N
SMILES
C1(C(=O)OC)=CCCN(C)C1.Br
Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.