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CAS NO.22465-48-1
1(1-5)Metric Ton1(2-5)Metric Ton
| Molecular Formula | C64H91CoN13O16P- |
| Molar Mass | 1388.39 |
| Melting Point | >3000C. |
| Solubility | Soluble in water. Some decomposition may occur on drying. |
| Appearance | Solid |
| Color | Dark Red |
| Merck | 14,4809 |
| Storage Condition | 2-8°C |
| WGK Germany | 3 |
| RTECS | GG3820000 |
| HS Code | 2936260000 |
| Introduction | Hydroxycobalt amine salts include hydroxycobalt amine acetate, hydroxycobalt amine hydrochloride, and hydroxycobalt amine sulfate. They are vitamin B12 series products are included in the European Pharmacopoeia. Because of their long stay in the body, they are called long-acting B12. It is an octahedral structure centered on cobalt ions, cobalt hydroxylamine acetate. Hydroxycobalamin salt is a dark red crystal or crystalline powder with strong hygroscopicity. It is a vitamin drug. It is used to treat and prevent vitamin B12 deficiency, treat peripheral neuropathy and megaloblastic anemia. High-dose injection can be used to treat acute sodium cyanide poisoning, tobacco poison amblyopia and Leber's optic nerve atrophy. |
| Physiological functions and effects | Hydroxycobalamin acetate is one of the vitamin B12 series products and is included in the European Pharmacopoeia. It is called long-acting B12. Vitamin B12 participates in various physiological functions of the human body: 1. Promote the development and maturation of red blood cells, make the body's hematopoietic function in a normal state, and prevent pernicious anemia; maintain the health of the nervous system 2. It exists in the form of coenzymes, which can increase the utilization rate of folic acid and promote the metabolism of carbohydrates, fats and proteins; 3. It has the effect of activating amino acids and promotes the biosynthesis of nucleic acids, it can promote the synthesis of protein, which plays an important role in the growth and development of infants and young children. 4. metabolize fatty acids and make fat, carbohydrate and protein be properly used by the body 5. eliminate irritability, concentrate attention, enhance memory and sense of balance 6. it is an indispensable vitamin for the sound function of the nervous system and participates in the formation of a lipoprotein in nerve tissue, |
| deficiency | deficiency of vitamin b12 will lead to liver function and digestive dysfunction, fatigue, mental depression, memory decline, reduced resistance, hematopoietic disorders, anemia, rough skin and dermatitis, etc. |
| production method | 2.4Kg mecobalamin is prepared into 2000 μg/ml mecobalamin solution, the PH is adjusted to 3.18 with 20% acetic acid, air stirring is turned on, the content of hydroxycobalamin acetate in the reaction solution is 98.3% under 17000LX, and the reaction solution is adsorbed on styrene macroporous adsorption resin column, the adsorption speed is 100L/h, and after washing with 450L acetone aqueous solution (where acetone: water = 5: 95) is used to spread the layer at a speed of 100L/h. When the outlet color changes from light red to colorless, 350L 40% acetone aqueous solution is analyzed through the resin column at a speed of 100 ~ 250L/h, red crystalline stock solution is collected, and stirring is started, add 600L acetone solution with a density of 0.810 g/ml to the crystalline stock solution, stir for 1h, let stand for 4h, filter by suction to obtain 2.39Kg of hydroxycobalamin acetate, the product yield is 99.6%, the content is 98.22%, and the related substances are 1.20%. At present, the production methods of hydroxycobalt amine salt are mainly as follows. (1) Use cyanocobalamin as the precursor to add a chemical reagent for chemical reaction, and then the extraction method is the solvent method, that is: after extraction with phenol-chloroform, acetone, and carbon tetrachloride, the solution is treated with hydroxycobalt The corresponding acid of the amine salt adjusts the PH to convert it into the corresponding hydroxycobalt amine salt, and then statically crystallizes, suction and drying to obtain hydroxycobalt amine salt. The process of preparing hydroxycobalt amine salt by solvent method has not been adopted because of its use of a large number of organic solvents, complex operation, heavy environmental pollution and great occupational hazards. (2) The precursor used is cyanocobalamin. Chemical reagents such as metaphite, sulfamic acid, sodium nitrite, glacial acetic acid and the like are added to the reaction, and the reaction solution of hydroxycobalamin is obtained after 6~9h of reaction at a certain temperature is controlled. After being adsorbed and analyzed by macroporous resin column, the solution is converted into the corresponding hydroxycobalt amine salt by adjusting the PH with the corresponding acid of hydroxycobalt amine salt, after static crystallization, suction and drying, hydroxycobalt amine salt is obtained. The disadvantage of this process is that because cyanocobalamin is a precursor, its properties are stable, and more than 4 chemical substances need to be added to the reaction to promote the completion of the reaction. At the same time, the temperature and PH must be strictly controlled during the reaction. Therefore, the reaction is not easy to control. And the product is more complicated. |
| biological activity | Hydroxocobalamin acetate is an injectable natural vitamin B12 with good adverse reaction characteristics and can be used for related research on vitamin B12 deficiency (including pernicious anemia). |
| target | the cobalt atom of hydroxocobalamin binds cyanide and nitric oxide (no) and hydroxocobalamin attenuates vascular responses to no in vitro . |
Mol Download Chemical properties
CAS:
22465-48-1
MF:
C64H91CoN13O16P-
MW:
1388.39
EINECS:
245-019-7
MDL No.:
MFCD00082532
Melting point:
>3000C.
storage temp.
2-8°C
solubility
Soluble in water. Some decomposition may occur on drying.
form
Solid
color
Dark Red
Merck
14,4809
LogP
-2.812 (est)