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CAS NO.16009-13-5
98%(500-1000)Kilogram98%(100-500)Metric Ton
| Molecular Formula | C34H31ClFeN4O4- |
| Molar Mass | 650.94 |
| Melting Point | 300 °C |
| Boling Point | °Cat760mmHg |
| Water Solubility | practically insoluble |
| Solubility | Easily soluble in dilute alkali solution, slightly soluble in alcohol, insoluble in dilute acid and water |
| Appearance | Black powder |
| Color | black |
| Exposure Limit | ACGIH: TWA 1 mg/m3NIOSH: TWA 1 mg/m3 |
| Merck | 14,4644 |
| BRN | 5229914 |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. Combustible. |
| Sensitive | Sensitive to light |
| MDL | MFCD00010726 |
| Physical and Chemical Properties | Heme is a red blood element in the blood and muscle of higher animals. It exists in red blood cells and binds to proteins to form complex proteins, namely hemoglobin (Hb) or myoglobin (Mb). Hb is a carrier that transports O2 and a portion of CO2, and is a buffering substance that maintains a constant pH of the blood. Under certain conditions, the heme can be separated from the protein. Heme is formed by complexation of protoporphyrin IX with iron (II). Heme crystals are blue-black, insoluble in water, soluble in acidic acetone, alkaline aqueous solution, easy to form polymer in solution. There is a resonance structure in its molecule and its properties are stable. Hemin (Hemin) is black green amorphous or long needle-like crystals, insoluble in water, soluble in acidic acetone and alkaline water. The molecular formula C34H32ClFe (III) N4O4 has a molecular weight of 651.96. Mainly used for anti-anemia, anticancer drug raw materials. 1930h. Fischer (Germany) received the Nobel Prize in Chemistry for the synthesis of heme. The heme is nitrated, and the iron ion is released, and the appropriate amount of 1, 10-phenanthroline is quantitatively formed in the buffer solution of pH 4.6 to form the orange-red complex by spectrophotometry in (510±1). Determination of iron ion content in heme at nm. The results showed that the orange-red complex formed by iron ion and 1, 10-phenanthroline had the maximum absorption at the wavelength of (510±1)nm and was in the range of 0.4-2.8 μg/ml, the correlation coefficient r = 0.9999. The average recovery X = 98.87%,RSD = 0.58%. |
| Overview | Hemin is a metal porphyrin compound with a simpler structure. It is formed by the complexation of a molecule of ferrous iron and protoporphyrin. It is a natural heme (heme) in vitro group substitution, and its chemical properties are similar to heme. Heme, as an indispensable small molecule in organisms, widely exists in various animals, plants, microorganisms, algae and other organisms. Wien Bio extracts hemin from livestock and poultry blood through its own patented technology. Through research and practice, it is found that hemin has a significant effect on alleviating abiotic stress in plants. |
| Application | Heme chloride (also known as porphyrin, hematoporphyrin, heme chloride, heme) is extracted from pig and bovine blood and is recognized by modern medicine as a biological iron source for preventing and treating iron deficiency anemia, with high absorption rate and good effect. It has no iron smell and does not stimulate the gastrointestinal tract. It is the first choice for the production of iron supplement food, medicine, health care products and cosmetics. |
| efficacy and action | Hemin is both a synthetic substrate for HO-1 and an accelerator for HO-1, which can induce the activity of HO-1, improve the ability of plants to resist oxidative stress and regulate plant metabolism. Studies have found that hemin, as an inducer of HO-1, can significantly induce the expression of HO-1 by exogenous addition, and alleviate the growth inhibition and oxidative stress caused by heavy metal stress by regulating the antioxidant system of crop roots. At the same time, hemin can alleviate osmotic stress caused by salt stress. In addition, hemin can also promote the accumulation of fresh weight of plants and the growth of taproots. |
| use | in the food industry, heme can replace nitrite and synthetic pigment in meat products; in the pharmaceutical industry, heme can be used as a semi-synthetic bilirubin raw material, and can be used to prepare anti-cancer drugs; clinically, heme can be made into heme iron tonic. The nutritional supplement (iron fortifier) is extracted from pig blood. It is recognized by modern medicine to prevent and treat iron deficiency anemia, with high absorption rate and good effect. The biological iron source has no iron smell and does not irritate the intestines and stomach. It is the first choice for the production of natural iron supplement food, medicine, health care products and cosmetics. Biochemical research; used as a blood test stain; used for the preparation of hematoporphyrin hydrochloride |
| production methods | heme preparation methods include base-organic solvent method, glacial acetic acid method, acetone method, methanol or methanol-ethanol method, ion exchange cellulose method. Methods 60L of methanol and 1kg of diethylamine were added into the reaction tank by 1. base-organic solvent method, stirred evenly, 5kg of fresh bovine blood powder was added, stirred and extracted at 45 ℃ for 1h, cooled and filtered, filtrate was concentrated to 5L, glacial acetic acid 10L and strontium chloride 200g were added, residual methanol was removed by heating and distilled, heated to 100-102 ℃ for 1h, cooled and filtered, and hemin crystals were collected. The hemin crystals were washed with glacial acetic acid, water, and acetone in turn, and dried to prepare 85g of hemin. Bovine blood powder [methanol, diethylamine] →[45 ℃, 1h][filtration] → filtrate [ice Hac, SrCl2]→[100-102 ℃, 1h][filtration, washing, drying] → heme 60L methanol and 5kg spray-dried bovine red blood cells are added to the reaction tank, stirred evenly, extracted at 40 ℃ for 30min, cooled, filtered, filtrate concentrated to 5L, and glacial acetic acid 10L is added, 100g of sodium chloride, add 2L of water to dissolve, heat distillation to remove residual methanol, heat to 100 ℃ for 1h, cool, filter, and collect hemin crystals. The hemin crystals were washed with glacial acetic acid and water, dried, and 65g of hemin was prepared. Bovine red blood cells [methanol] →[40 ℃, 30min][filtration] → filtrate [ice Hac, NaCl, H2O]→[100 ℃, 1h][filtration, washing, drying] → preparation of heme chlorinated heme 300kg of fresh blood powder, 1200L of methanol, 30kg of dichloroacetic acid, stirring evenly, stirring with 45 ℃ for 1h, cooling, filtering, filtrate concentrated to dry to obtain 45kg of heme. Fresh blood meal [methanol, dichloroacetic acid] →[45 ℃, 1h][filtration, concentration] → preparation of heme hemin 45kg is taken, 100L of glacial acetic acid containing 2kg NaCl is added, boiled and refluxed for 1h, cooled and filtered to obtain hemin, washed with glacial acetic acid and water in turn, dried to obtain hemin 4.8kg. Heme [mixed solvent of NaCl and glacial acetic acid] → [boiling for 1h][washing, drying] → preparation of extracting acidic blood powder 2. methanol-ethanol mixed solvent by hemin chloride method take 100kg of blood powder, add 0.6mol/L HCl solution 100kg, stir hemolysis, spray drying to obtain 40kg of acidic blood powder. Blood Powder [HCl]→ Preparation of Acid Blood Powder Heme 40kg of acid blood powder was extracted three times with a mixed solvent composed of 90% ethanol, 6% methanol and 4% water. The dosage of the mixed solvent was 800L, 300L and 200L respectively. The supernatant was combined and distilled and concentrated to obtain heme. Acid blood powder [mixed solvent] → [extract 3 times] supernatant [concentrate] → heme. |
Mol Download Chemical properties
CAS:
16009-13-5
MF:
C34H31ClFeN4O4-
MW:
650.94
EINECS:
240-140-1
MDL No.:
MFCD00010726
Melting point:
300 °C
storage temp.
2-8°C
solubility
1.4 M NaOH: soluble25mg/mL
form
crystal
color
black
Water Solubility
practically insoluble
Merck
14,4644
BRN
5229914
Exposure limits
ACGIH: TWA 1 mg/m3
NIOSH: TWA 1 mg/m3
Stability:
Stable. Incompatible with strong oxidizing agents. Combustible.
InChIKey
BTIJJDXEELBZFS-HXFTUNQESA-K
SMILES
[Cl-][Fe+3]123[N-]4C5C(C)=C(C=C)C4=CC4C(C)=C(C=C)C(=CC6=C(C)C(CCC(=O)[O-])=C(C=C7C(CCC(=O)[O-])=C(C)C(C=5)=N17)[N-]26)N3=4.[H+]
Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.
We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.
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